• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

氧氟沙星致幻觉。

Ofloxacin-induced hallucinations.

机构信息

Department of Pediatrics, ESI-PGIMSR and MGM Hospital, Parel, Mumbai, Maharashtra, India.

出版信息

Indian J Pharmacol. 2013 Mar-Apr;45(2):189-90. doi: 10.4103/0253-7613.108316.

DOI:10.4103/0253-7613.108316
PMID:23716899
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3660935/
Abstract

Drug-induced hallucinations are not uncommon, and may be misdiagnosed as psychiatric illness leading to unnecessary treatment with antipsychotics. If a temporal association of use of a drug having the potential to cause hallucinations is present, mere withdrawal of the drug causes complete improvement in the symptoms. There are reports of various untoward central nervous system adverse events following administration of fluoroquinolones, including delirium, hallucinations and psychosis, even after a single dose. We describe a 5-year-old girl who suffered visual hallucinations following ofloxacin use.

摘要

药物引起的幻觉并不少见,可能被误诊为精神疾病,从而导致不必要的使用抗精神病药物治疗。如果存在某种药物的使用与幻觉发生之间的时间关联,仅仅停用该药物就会使症状完全改善。氟喹诺酮类药物使用后会出现各种中枢神经系统不良事件,包括谵妄、幻觉和精神病,甚至在单次用药后也会出现。我们描述了一例 5 岁女孩在使用氧氟沙星后出现视觉幻觉。

相似文献

1
Ofloxacin-induced hallucinations.氧氟沙星致幻觉。
Indian J Pharmacol. 2013 Mar-Apr;45(2):189-90. doi: 10.4103/0253-7613.108316.
2
Moxifloxacin-Induced Visual Hallucinations: A Case Report and Review of the Literature.莫西沙星诱发的视幻觉:一例病例报告及文献综述
J Pharm Pract. 2017 Jun;30(3):375-377. doi: 10.1177/0897190016637987. Epub 2016 Mar 21.
3
Levofloxacin-induced delirium.左氧氟沙星所致谵妄
Neurol Sci. 2009 Apr;30(2):159-61. doi: 10.1007/s10072-009-0027-9. Epub 2009 Feb 3.
4
Phenytoin-induced visual disturbances mimicking Delirium Tremens in a child.苯妥英钠致儿童视幻觉,酷似震颤谵妄。
Eur J Paediatr Neurol. 2010 Sep;14(5):460-3. doi: 10.1016/j.ejpn.2010.05.008. Epub 2010 Jun 17.
5
Levofloxacin-induced delirium: is it a dangerous drug in patients with renal dysfunction?左氧氟沙星致精神错乱:肾功能障碍患者使用该药是否危险?
Ren Fail. 2012;34(5):634-6. doi: 10.3109/0886022X.2012.660855. Epub 2012 Mar 6.
6
[Levofloxacin-induced neurological adverse effects such as convulsion, involuntary movement (tremor, myoclonus and chorea like), visual hallucination in two elderly patients].[两名老年患者出现左氧氟沙星诱发的神经不良反应,如惊厥、不自主运动(震颤、肌阵挛和舞蹈样动作)、视幻觉]
Nihon Ronen Igakkai Zasshi. 1999 Mar;36(3):213-7. doi: 10.3143/geriatrics.36.213.
7
Levofloxacin-induced delirium with psychotic features.左氧氟沙星诱发的伴有精神病性症状的谵妄。
Gen Hosp Psychiatry. 2008 Jul-Aug;30(4):381-3. doi: 10.1016/j.genhosppsych.2007.11.003.
8
Safety profile of the fluoroquinolones: focus on levofloxacin.氟喹诺酮类药物的安全性概况:以左氧氟沙星为例。
Drug Saf. 2010 May 1;33(5):353-69. doi: 10.2165/11536360-000000000-00000.
9
Levofloxacin-induced tactile hallucination and acute anxiety reaction.左氧氟沙星致触觉幻觉和急性焦虑反应。
Indian J Pharmacol. 2019 Mar-Apr;51(2):123-125. doi: 10.4103/ijp.IJP_291_17.
10
Acute rhabdomyolysis associated with ofloxacin/levofloxacin therapy.与氧氟沙星/左氧氟沙星治疗相关的急性横纹肌溶解症。
Ann Pharmacother. 2005 Jan;39(1):146-9. doi: 10.1345/aph.1E285. Epub 2004 Nov 23.

引用本文的文献

1
Psychiatric disorders associated with fluoroquinolones: a pharmacovigilance analysis of the FDA adverse event reporting system database.与氟喹诺酮类药物相关的精神障碍:对美国食品药品监督管理局不良事件报告系统数据库的药物警戒分析
Front Pharmacol. 2024 Oct 14;15:1435923. doi: 10.3389/fphar.2024.1435923. eCollection 2024.
2
Depressive and Other Adverse CNS Effects of Fluoroquinolones.氟喹诺酮类药物的抑郁及其他中枢神经系统不良反应
Pharmaceuticals (Basel). 2023 Aug 4;16(8):1105. doi: 10.3390/ph16081105.
3
Ofloxacin induced psychosis-A rare complication.氧氟沙星诱发的精神病——一种罕见的并发症。
J Anaesthesiol Clin Pharmacol. 2022 Apr-Jun;38(2):339-340. doi: 10.4103/joacp.JOACP_141_19. Epub 2022 May 2.
4
The Pharmacology of Visual Hallucinations in Synucleinopathies.突触核蛋白病中视幻觉的药理学
Front Pharmacol. 2019 Dec 9;10:1379. doi: 10.3389/fphar.2019.01379. eCollection 2019.
5
High Dose Ofloxacin-induced Bimodal Hallucinations in a 4 Years Old Child.高剂量氧氟沙星致一名4岁儿童出现双峰性幻觉
Clin Psychopharmacol Neurosci. 2017 Nov 30;15(4):416-417. doi: 10.9758/cpn.2017.15.4.416.
6
Neuropsychiatric Effects of Antimicrobial Agents.抗菌药物的神经精神不良反应。
Clin Drug Investig. 2017 May;37(5):423-437. doi: 10.1007/s40261-017-0498-z.
7
Recurrent mania consequent to quinolones exposure: A case report and review of literature.喹诺酮类药物暴露后复发性躁狂症:一例病例报告及文献综述
J Family Med Prim Care. 2016 Jan-Mar;5(1):163-5. doi: 10.4103/2249-4863.184654.

本文引用的文献

1
Quinolones: review of psychiatric and neurological adverse reactions.喹诺酮类药物:精神和神经系统不良反应综述。
Drug Saf. 2011 Jun 1;34(6):465-88. doi: 10.2165/11587280-000000000-00000.
2
Reversible cerebellar toxicity during treatment with ornidazole: the first case report.奥硝唑治疗期间可逆性小脑毒性:首例病例报告
J Neurol Neurosurg Psychiatry. 2010 Mar;81(3):349-50. doi: 10.1136/jnnp.2009.178897.
3
[Aseptic meningitis ornidazole-induced in the course of infectious endocarditis].[奥硝唑在感染性心内膜炎病程中诱发的无菌性脑膜炎]
Rev Med Interne. 2002 Sep;23(9):784-7. doi: 10.1016/s0248-8663(02)00675-6.
4
Fluoroquinolone toxicity profiles: a review focusing on newer agents.氟喹诺酮类药物的毒性概况:聚焦新型药物的综述
Clin Infect Dis. 1999 Feb;28(2):352-64. doi: 10.1086/515104.
5
Structure-activity and structure-side-effect relationships for the quinolone antibacterials.喹诺酮类抗菌药物的构效关系和构效副作用关系。
J Antimicrob Chemother. 1994 Apr;33(4):685-706. doi: 10.1093/jac/33.4.685.
6
[Peripheral neuropathy during treatment with ornidazole].[奥硝唑治疗期间的周围神经病变]
Ann Fr Anesth Reanim. 1984;3(4):312-4. doi: 10.1016/s0750-7658(84)80127-6.
7
Ofloxacin-induced psychosis.氧氟沙星所致精神病
Br J Psychiatry. 1987 Oct;151:563-4. doi: 10.1192/bjp.151.4.563.
8
Safety profile of ofloxacin: the Italian data base.
Infection. 1986;14 Suppl 4:S335-7. doi: 10.1007/BF01661312.
9
Safety of ofloxacin--adverse drug reactions reported during phase-II studies in Europe and in Japan.
Infection. 1986;14 Suppl 4:S332-4. doi: 10.1007/BF01661311.
10
Pharmacokinetics and serum bactericidal activities of quinolones in combination with clindamycin, metronidazole, and ornidazole.喹诺酮类药物与克林霉素、甲硝唑和奥硝唑联合应用的药代动力学及血清杀菌活性
Antimicrob Agents Chemother. 1990 Dec;34(12):2407-14. doi: 10.1128/AAC.34.12.2407.