Rai Shalu, Kaur Mandeep, Kaur Sandeep, Arora Sapna Panjwani
Departments of Oral Medicine and Radiology, Institute of Dental Studies and Technologies, Kadrabad, Modinagar, Uttar Pradesh, India.
Indian J Hum Genet. 2012 Sep;18(3):276-84. doi: 10.4103/0971-6866.107976.
Recent exciting discoveries isolated dental stem cells from the pulp of the primary and permanent teeth, from the periodontal ligament, and from associated healthy tissues. Dental pulp stem cells (DPSCs) represent a kind of adult cell colony which has the potent capacity of self-renewing and multilineage differentiation. Stem cell-based tooth engineering is deemed as a promising approach to the making of a biological tooth (bio-tooth) or engineering of functional tooth structures. Dental professionals have the opportunity to make their patients aware of these new sources of stem cells that can be stored for future use as new therapies are developed for a range of diseases and injuries. The aim of this article is to review and understand how dental stem cells are being used for regeneration of oral and conversely nonoral tissues. A brief review on banking is also done for storing of these valuable stem cells for future use.
最近令人兴奋的发现是,从乳牙和恒牙的牙髓、牙周韧带以及相关健康组织中分离出了牙干细胞。牙髓干细胞(DPSCs)是一种具有自我更新和多向分化能力的成体细胞群体。基于干细胞的牙齿工程被认为是制造生物牙齿(生物牙)或构建功能性牙齿结构的一种有前景的方法。牙科专业人员有机会让患者了解这些新的干细胞来源,随着针对一系列疾病和损伤的新疗法的开发,这些干细胞可被储存起来供未来使用。本文的目的是回顾和了解牙干细胞如何用于口腔组织以及相反地用于非口腔组织的再生。还对储存这些宝贵干细胞以供未来使用的库进行了简要综述。