基于干细胞的牙和牙周组织再生。

Stem cell-based tooth and periodontal regeneration.

机构信息

Molecular Laboratory for Gene Therapy and Tooth Regeneration, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing, China.

Laboratory of Tissue Regeneration and Immunology and Department of Periodontics, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Capital Medical University, Beijing, China.

出版信息

Oral Dis. 2018 Jul;24(5):696-705. doi: 10.1111/odi.12703. Epub 2017 Jul 24.

DOI:10.1111/odi.12703

PMID:28636235

Abstract

Currently regeneration of tooth and periodontal damage still remains great challenge. Stem cell-based tissue engineering raised novel therapeutic strategies for tooth and periodontal repair. Stem cells for tooth and periodontal regeneration include dental pulp stem cells (DPSCs), periodontal ligament stem cells (PDLSCs), stem cells from the dental apical papilla (SCAPs), and stem cells from human exfoliated deciduous teeth (SHEDs), dental follicle stem cells (DFSCs), dental epithelial stem cells (DESCs), bone marrow mesenchymal stem cells (BMMSCs), adipose-derived stem cells (ADSCs), embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). To date, substantial advances have been made in stem cell-based tooth and periodontal regeneration, including dentin-pulp, whole tooth, bioroot and periodontal regeneration. Translational investigations have been performed such as dental stem cell banking and clinical trials. In this review, we present strategies for stem cell-based tissue engineering for tooth and periodontal repair, and the translational studies.

摘要

目前，牙齿和牙周损伤的再生仍然是一个巨大的挑战。基于干细胞的组织工程为牙齿和牙周修复提出了新的治疗策略。用于牙齿和牙周再生的干细胞包括牙髓干细胞（DPSCs）、牙周韧带干细胞（PDLSCs）、牙乳头干细胞（SCAPs）和人脱落乳牙干细胞（SHEDs）、牙囊干细胞（DFSCs）、牙上皮干细胞（DESCs）、骨髓间充质干细胞（BMMSCs）、脂肪来源干细胞（ADSCs）、胚胎干细胞（ESCs）和诱导多能干细胞（iPSCs）。迄今为止，基于干细胞的牙齿和牙周再生已经取得了实质性进展，包括牙本质牙髓、全牙、生物牙根和牙周再生。已经进行了转化研究，如牙干细胞库和临床试验。在这篇综述中，我们介绍了基于干细胞的组织工程用于牙齿和牙周修复的策略，以及转化研究。