Clifford Anton G, Gabriel Stefan M, O'Connell Mary, Lowe David, Miller Larry E, Block Jon E
Moximed, Inc, Hayward, CA, USA.
Med Devices (Auckl). 2013 May 17;6:69-76. doi: 10.2147/MDER.S44385. Print 2013.
Symptomatic medial compartment knee osteoarthritis (OA) is the leading cause of musculoskeletal pain and disability in adults. Therapies intended to unload the medial knee compartment have yielded unsatisfactory results due to low patient compliance with conservative treatments and high complication rates with surgical options. There is no widely available joint-unloading treatment for medial knee OA that offers clinically important symptom alleviation, low complication risk, and high patient acceptance. The KineSpring(®) Knee Implant System (Moximed, Inc, Hayward, CA, USA) is a first-of-its-kind, implantable, extra-articular, extra-capsular prosthesis intended to alleviate knee OA-related symptoms by reducing medial knee compartment loading while overcoming the limitations of traditional joint-unloading therapies. Preclinical and clinical studies have demonstrated excellent prosthesis durability, substantial reductions in medial compartment and total joint loads, and clinically important improvements in OA-related pain and function. The purpose of this report is to describe the KineSpring System, including implant characteristics, principles of operation, indications for use, patient selection criteria, surgical technique, postoperative care, preclinical testing, and clinical experience. The KineSpring System has potential to bridge the gap between ineffective conservative treatments and irreversible surgical interventions for medial compartment knee OA.
有症状的膝关节内侧间室骨关节炎（OA）是成年人肌肉骨骼疼痛和残疾的主要原因。旨在减轻膝关节内侧间室负荷的治疗方法，由于患者对保守治疗的依从性低以及手术选择的高并发症发生率，效果并不理想。目前尚无广泛应用的可减轻膝关节内侧OA症状、并发症风险低且患者接受度高的关节卸载治疗方法。KineSpring（®）膝关节植入系统（美国加利福尼亚州海沃德市的Moximed公司）是同类首创的可植入、关节外、囊外假体，旨在通过减轻膝关节内侧间室负荷来缓解与膝关节OA相关的症状，同时克服传统关节卸载疗法的局限性。临床前和临床研究已证明该假体具有出色的耐用性，可大幅降低内侧间室和全关节负荷，并在与OA相关的疼痛和功能方面取得具有临床意义的改善。本报告的目的是描述KineSpring系统，包括植入物特性、操作原理、使用适应症、患者选择标准、手术技术、术后护理、临床前测试和临床经验。KineSpring系统有潜力填补膝关节内侧间室OA无效保守治疗与不可逆手术干预之间的空白。
