Astolfi P, Martinetti M, Gigli-Berzolari F, Cuccia M
Department of Genetics and Microbiology, University of Pavia, Italy.
Tissue Antigens. 1990 Apr;35(4):172-7. doi: 10.1111/j.1399-0039.1990.tb01775.x.
The secondary sex ratio (male births of total births) variation was investigated as a function of MHC antigens. Previous studies have indicated that at conception male zygotes are more frequent than female ones and abortions of male fetuses prevail. The present investigation addresses the question whether the histocompatibility relationships either between parents or between mother and offsprings may favor or hinder the outcome of pregnancy: particular combinations may cause distortions in the sex ratio. The results of the analysis of a sample of fertile families, demonstrate that, in first parities, female births are favored when parents share antigens at both HLA-A and -B loci (S.R. = 0.389), and mothers and fetuses share antigens at the HLA-B locus (S.R. = 0.222). The lack of antigens shared by parents at the three loci HLA-A, -B and -DR increases first male births (S.R. = 0.696). In the case of fetal maternal histocompatibility at DR locus only a slight, non-significant, increase in male first births (S.R. = 0.667) was observed. The effect of histocompatibility at HLA-B locus alone requires further investigation in order to assess the possible selective effect against male histocompatible embryos.
研究了次要性别比（男婴出生数占总出生数的比例）随主要组织相容性复合体（MHC）抗原的变化情况。先前的研究表明，受孕时雄性合子比雌性合子更常见，且男性胎儿的流产更为普遍。本研究探讨了父母之间或母亲与后代之间的组织相容性关系是否会有利于或阻碍妊娠结果这一问题：特定的组合可能会导致性别比失衡。对可育家庭样本的分析结果表明，在头胎中，当父母在HLA - A和 - B位点都共享抗原时（性别比 = 0.389），以及母亲和胎儿在HLA - B位点共享抗原时（性别比 = 0.222），生女婴更受青睐。父母在HLA - A、 - B和 - DR这三个位点都不共享抗原时，头胎生男婴的比例增加（性别比 = 0.696）。在仅DR位点存在胎儿与母亲组织相容性的情况下，观察到头胎生男婴仅有轻微的、不显著的增加（性别比 = 0.667）。仅HLA - B位点组织相容性的影响需要进一步研究，以评估对与母亲组织相容性的男性胚胎可能存在的选择作用。
