Astolfi P, Cuccia M, Caruso C, Favoino B, Fazzari M, Mantovani V, Lulli P, Illeni M T, Martinetti M
Department of Genetics and Microbiology, Buzzati Traverso University of Pavia, Italy.
Hum Hered. 1996 May-Jun;46(3):155-65. doi: 10.1159/000154345.
We analysed the effect of HLA loci on the secondary sex ratio, and investigated whether allele sharing between parents and between mother and child, or child homozygosity, affected the viability of male embryos, which are generally less resistant to unfavourable conditions during pregnancy. The sharing conditions at the B and DR loci showed significantly differing effects: HLA-B seemed to favour female births, while, in pregnancies subsequent to the first, HLA-DR seemed to favour male births. Both HLA-B and DR loci seemed to work through immunological mechanisms.
我们分析了HLA基因座对出生性别比的影响，并研究了父母之间以及母婴之间的等位基因共享或孩子的纯合性是否会影响雄性胚胎的活力，雄性胚胎在孕期通常对不利条件的抵抗力较弱。B和DR基因座的共享情况显示出显著不同的影响：HLA - B似乎有利于生出女孩，而在第一胎后的妊娠中，HLA - DR似乎有利于生出男孩。HLA - B和DR基因座似乎都是通过免疫机制起作用的。
