Radvany R M, Vaisrub N, Ober C, Patel K M, Hecht F
Tissue Antigens. 1987 Jan;29(1):34-42. doi: 10.1111/j.1399-0039.1987.tb01547.x.
Maternal-fetal HLA-DR antigen sharing has been reported to affect the sex ratio of first-born. We therefore studied offspring sex ratios and birth orders in 66 families in which parents shared one or more HLA-DR antigens as compared to 61 families with no parental HLA-DR sharing. A significant excess of males was found among first-born children who were HLA-DR compatible with their mothers compared to first-born HLA-DR incompatible children of couples sharing HLA-DR antigens and couples not sharing HLA-DR antigens. Increased numbers of males may persist among children of higher birth orders in families where parents share both HLA-DR antigens, but not among couples sharing only one HLA-DR antigen. We hypothesize that the presence of the H-Y antigen in the male fetus may provide the necessary stimulus for a successful pregnancy in HLA-DR compatible pregnancies and may explain the excess of male births in the general population.
据报道，母胎HLA - DR抗原共享会影响头胎的性别比例。因此，我们研究了66个父母共享一种或多种HLA - DR抗原的家庭中的后代性别比例和出生顺序，并与61个父母不共享HLA - DR抗原的家庭进行了比较。与父母共享HLA - DR抗原的夫妇以及不共享HLA - DR抗原的夫妇的头胎HLA - DR不相容的孩子相比，与母亲HLA - DR相容的头胎孩子中男性明显过多。在父母共享两种HLA - DR抗原的家庭中，较高出生顺序的孩子中男性数量可能持续增加，但在仅共享一种HLA - DR抗原的夫妇中则不会。我们推测，男性胎儿中H - Y抗原的存在可能为HLA - DR相容妊娠的成功妊娠提供必要的刺激，并可能解释了普通人群中男性出生过多的现象。
