Turning Point Alcohol & Drug Centre, Eastern Health, Melbourne, Australia.
Aust N Z J Psychiatry. 2013 Sep;47(9):859-67. doi: 10.1177/0004867413491155. Epub 2013 May 29.
Clinical studies consistently identify alcohol- and drug-related treatment populations as more likely to die prematurely compared with an age-matched general population. However, demographic characteristics and primary drug of concern as predictors of mortality risk following treatment have not been adequately explored. This paper examines relationships between substance use, demographic factors and mortality among alcohol and drug treatment clients.
A retrospective cohort incorporating 7 years of data was utilised to examine mortality outcomes in the 2 years following treatment among Victorian clients recorded on the Alcohol and Drug Information Service (ADIS) database by linking partial client identifiers with the National Death Index (NDI). A cohort of 18,686 clients engaged in at least one course of treatment over a 12-month period was included. Analysis was of crude and standardised mortality rates across client groups in terms of the presenting drug of concern for treatment and demographic characteristics.
A higher risk of premature death was associated with older age, being male, not being employed, living alone, medical and psychiatric comorbidity, recent injecting, and a history of intensive drug treatment access. Alcohol treatment clients had the worst prognosis. After adjustment for client characteristics, alcohol treatment clients experienced a significantly higher rate of death compared with other clients.
Findings from these previously unexplored data highlight the need to increase awareness of the range and magnitude of risks associated with harmful alcohol use, and to identify approaches to enhance treatment effectiveness to reduce negative outcomes following treatment for populations at elevated risk of harm.
临床研究一致表明,与年龄匹配的普通人群相比,酒精和药物相关治疗人群更有可能过早死亡。然而,作为治疗后死亡风险预测因素的人口统计学特征和主要关注药物,尚未得到充分探讨。本文研究了酒精和药物治疗患者的物质使用、人口统计学因素与死亡率之间的关系。
利用包含 7 年数据的回顾性队列,通过将部分客户标识符与国家死亡指数(NDI)链接,将维多利亚州客户的治疗后 2 年内的死亡率结果纳入酒精和毒品信息服务(ADIS)数据库中记录的治疗情况。纳入了在 12 个月内至少接受过一次治疗的 18686 名客户。根据治疗中出现的主要关注药物和人口统计学特征,对客户群体的死亡率进行了粗死亡率和标准化死亡率分析。
年龄较大、男性、未就业、独居、有医疗和精神共病、近期注射毒品和有密集药物治疗史与过早死亡的风险增加相关。酒精治疗患者的预后最差。在调整了客户特征后,与其他客户相比,酒精治疗患者的死亡率显著更高。
这些以前未被探索的数据结果强调了需要提高对与有害酒精使用相关的一系列风险的认识,并确定增强治疗效果的方法,以降低处于高风险人群治疗后的不良后果。