van Aalderen W M, Postma D S, Koëter G H, Gerritsen J, Knol K
Department of Pediatrics, University Hospital, Groningen, The Netherlands.
Agents Actions. 1990 Apr;30(1-2):258-60. doi: 10.1007/BF01969054.
In a study of two groups of nine allergic asthmatic children, consisting of one group with (group I) and one group without (group II) increased nocturnal airflow obstruction, we determined whether an increase in vagal activity, or inflammatory mediators like histamine are responsible for the nocturnal increase in airflow obstruction. The results of investigations in the two groups of asthmatics were compared to the results of an age matched control group. Forced expiratory volume in one second (FEV1) and electrocardiogram recordings of one minute were obtained every 4 hours during 24 hours. Heart rate and sinus arrhythmia gap were used to express vagal activity indirectly. N tau-methylhistamine was determined in urine samples collected in periods of 4 hours between the measurements. In group I, overall N tau-methylhistamine excretion was on a higher level than in both other groups, and was significantly higher overnight. Parasympathetic stimulation did not seem of importance to the increase of airflow obstruction at night.
在一项针对两组各9名过敏性哮喘儿童的研究中，一组（第一组）存在夜间气流阻塞增加的情况，另一组（第二组）则没有，我们确定了迷走神经活动增加或组胺等炎症介质是否是夜间气流阻塞增加的原因。将两组哮喘患者的调查结果与年龄匹配的对照组的结果进行了比较。在24小时内，每4小时测量一次一秒用力呼气量（FEV1）和一分钟心电图记录。心率和窦性心律失常差值被用于间接表示迷走神经活动。在测量期间，每4小时收集一次尿液样本，测定其中的N-甲基组胺。在第一组中，N-甲基组胺的总体排泄水平高于其他两组，且夜间显著更高。副交感神经刺激似乎对夜间气流阻塞的增加并不重要。
