Lang J M, Lieberman E, Ryan K J, Monson R R
Epidemiology and Biostatistics Section, Boston U. School of Public Health, MA 02118-2394.
Am J Epidemiol. 1990 Aug;132(2):304-9. doi: 10.1093/oxfordjournals.aje.a115659.
In 1977-1980, over 12,000 pregnant women being followed at the Boston Hospital for Women were interviewed and had their medical records reviewed. The effect of interpregnancy interval on the risk of preterm labor was estimated in 4,467 of these women whose previous pregnancy had resulted in a full-term live birth. The rate of preterm birth after the spontaneous onset of labor in this cohort was 3.8 percent. While the possibility of an increased risk of preterm labor for interpregnancy intervals of 3 months or less cannot be definitely excluded (adjusted odds ratio = 2.0, 95 percent confidence interval 0.7-5.4), no relation was found between other interpregnancy intervals and the risk of preterm labor. Earlier work from this same cohort showed a strong negative association between interpregnancy interval and small-for-gestational-age birth. Combining this with the results from the present study reinforces the importance of differentiating low birth weight due to preterm birth from that due to intrauterine growth retardation.
1977年至1980年期间，对在波士顿妇女医院接受随访的12000多名孕妇进行了访谈，并对她们的病历进行了审查。在这些前次妊娠为足月活产的妇女中，有4467人被评估了妊娠间隔对早产风险的影响。该队列中自然发动分娩后的早产率为3.8%。虽然不能完全排除妊娠间隔3个月或更短时间会增加早产风险的可能性（校正比值比=2.0，95%置信区间0.7 - 5.4），但未发现其他妊娠间隔与早产风险之间存在关联。来自同一队列的早期研究表明，妊娠间隔与小于胎龄儿出生之间存在强烈的负相关。将此与本研究结果相结合，强化了区分早产所致低出生体重与宫内生长迟缓所致低出生体重的重要性。
