Department of Nuclear Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, Hannover 30625, Germany.
Eur Heart J Cardiovasc Imaging. 2013 Aug;14(8):741-51. doi: 10.1093/ehjci/jet038. Epub 2013 May 29.
Cell- and molecule-based therapeutic strategies to support wound healing and regeneration after myocardial infarction (MI) are under development. These emerging therapies aim at sustained preservation of ventricular function by enhancing tissue repair after myocardial ischaemia and reperfusion. Such therapies will benefit from guidance with regard to timing, regional targeting, suitable candidate selection, and effectiveness monitoring. Such guidance is effectively obtained by non-invasive tomographic imaging. Infarct size, tissue characteristics, muscle mass, and chamber geometry can be determined by magnetic resonance imaging and computed tomography. Radionuclide imaging can be used for the tracking of therapeutic agents and for the interrogation of molecular mechanisms such as inflammation, angiogenesis, and extracellular matrix activation. This review article portrays the hypothesis that an integrated approach with an early implementation of structural and molecular tomographic imaging in the development of novel therapies will provide a framework for achieving the goal of improved tissue repair after MI.
细胞和分子治疗策略旨在支持心肌梗死后的伤口愈合和再生。这些新兴的治疗方法旨在通过增强心肌缺血再灌注后的组织修复，来持续保持心室功能。此类治疗方法将受益于关于时机、区域靶向、合适的候选者选择和效果监测的指导。这种指导可以通过非侵入性断层成像技术有效地获得。磁共振成像和计算机断层扫描可用于确定梗塞面积、组织特征、肌肉质量和心室几何形状。放射性核素成像可用于治疗剂的跟踪，并可用于询问炎症、血管生成和细胞外基质激活等分子机制。本文假设，在新型治疗方法的开发中，早期实施结构和分子断层成像的综合方法将为实现改善心肌梗死后组织修复的目标提供框架。
