Storkholm J H, Villadsen G E, Krogh K, Jørgensen C S, Gregersen H
Core Centre of Gastrointestinal Motility and Biomechanics, Aarhus University Hospital, Skejby Sygehus, Denmark.
Med Biol Eng Comput. 1997 Jan;35(1):21-6. doi: 10.1007/BF02510387.
The aim of the study is to devise a method for direct measurements of pressure, cross-sectional area (CSA) and wall thickness of a vessel when pressurised. Segments of porcine descending thoracic aorta from 22 and 35 kg pigs (in groups 1 and 2, respectively) and of abdominal aorta from 35 kg pigs are studied in vitro. Impedance planimetry provides measurements of the luminal pressure and CSA of the aorta. The wall thickness is measured simultaneously by means of 20 MHz A-mode ultrasound. The pressure, CSA and wall thickness are registered at different pressure at steady state. At maximum pressure, the CSAs are 107 +/- 10, 215 +/- 19 and 257 +/- 17 mm2 in the abdominal, group 1 and 2 segments, respectively. There is a difference between the abdominal group and groups 1 and 2 (p < 0.05), but not between group 1 and 2 segments (p > 0.2). At maximum pressure, the wall thickness is 0.52 +/- 0.04, 0.79 +/- 0.07 and 1.07 +/- 0.02 mm, in the abdominal group 1 and 2 segments, respectively (p < 0.05). The circumferential stress-strain relationship accorded well with stress = a x exp(b x strain). The stress-strain curve of the abdominal aortas is shifted to the left, indicating an increase (p < 0.05).
本研究的目的是设计一种方法，用于在血管受压时直接测量其压力、横截面积（CSA）和壁厚。对22千克和35千克猪（分别为第1组和第2组）的猪降胸主动脉段以及35千克猪的腹主动脉段进行体外研究。阻抗平面测量法可测量主动脉的腔内压力和CSA。通过20兆赫兹A模式超声同时测量壁厚。在稳态下，在不同压力下记录压力、CSA和壁厚。在最大压力时，腹主动脉段、第1组和第2组主动脉段的CSA分别为107±10、215±19和257±17平方毫米。腹主动脉组与第1组和第2组之间存在差异（p<0.05），但第1组和第2组主动脉段之间无差异（p>0.2）。在最大压力时，腹主动脉段、第1组和第2组主动脉段的壁厚分别为0.52±0.04、0.79±0.07和1.07±0.02毫米（p<0.05）。周向应力-应变关系与应力=a×exp（b×应变）符合良好。腹主动脉的应力-应变曲线向左移动，表明有所增加（p<0.05）。
