Siegle M L, Schmid H R, Ehrlein H J
Institute of Zoophysiology, University of Hohenheim, Stuttgart, Federal Republic of Germany.
Am J Physiol. 1990 Jul;259(1 Pt 1):G78-85. doi: 10.1152/ajpgi.1990.259.1.G78.
In the present study, effects of ileal infusions of nutrients on motor patterns of the proximal small intestine and on gastric emptying were investigated in dogs. An acaloric meal was administered orally, and equicaloric loads of amino acids, oleate, and glucose were infused into the ileum at different doses (0.3, 0.6, and 0.9 kJ/min). The computerized analysis of motor patterns was focused on the differentiation between stationary and propagated contractions recorded by closely spaced extraluminal strain gauges. All three nutrients exerted inhibitory effects on gastric emptying and on contraction force and frequency of the proximal small intestine. Additionally, the propulsive motor pattern induced by the acaloric meal was modulated by reducing the number of contraction waves and their length of spread. All the effects were dose dependent. Among the three nutrients, glucose significantly changed motility at lower doses compared with amino acids and oleate. We conclude that in dogs the ileal brake mechanism is induced by all three nutrients and that it influences not only contraction force and frequency but also the motor patterns of the proximal small intestine.
在本研究中，研究了犬回肠输注营养物质对近端小肠运动模式和胃排空的影响。口服给予无热量餐，并以不同剂量（0.3、0.6和0.9 kJ/分钟）将等热量的氨基酸、油酸酯和葡萄糖输注到回肠中。运动模式的计算机分析重点在于通过紧密间隔的腔外应变仪记录的静止收缩和传播收缩之间的区分。所有三种营养物质均对胃排空以及近端小肠的收缩力和频率产生抑制作用。此外，无热量餐诱导的推进性运动模式通过减少收缩波的数量及其传播长度而受到调节。所有这些作用均呈剂量依赖性。在这三种营养物质中，与氨基酸和油酸酯相比，葡萄糖在较低剂量时就能显著改变运动性。我们得出结论，在犬中，所有三种营养物质均可诱导回肠制动机制，并且它不仅影响收缩力和频率，还影响近端小肠的运动模式。
