Van Citters G W, Lin H C
Center for Diabetes Research, University of Southern California, USA.
Curr Gastroenterol Rep. 1999 Oct;1(5):404-9. doi: 10.1007/s11894-999-0022-6.
The "ileal brake" is the primary inhibitory feedback mechanism to control transit of a meal through the gastrointestinal tract in order to optimize nutrient digestion and absorption. Neurohormonal factors mediating this response continue to be identified. Recently, additional brakes that fine-tune transit have been described. When gut traffic control is disrupted, pathologic states characterized by malabsorption and impaired drug bioavailability manifest as diarrhea and malnutrition. An understanding of the importance of these nutrient-triggered brakes provides essential clues to future treatments of chronic diarrhea, malnutrition, and drug malabsorption.
“回肠制动”是控制食物在胃肠道中转运的主要抑制性反馈机制，以优化营养物质的消化和吸收。介导这种反应的神经激素因素仍在不断被发现。最近，已经描述了其他微调转运的制动机制。当肠道运输控制被破坏时，以吸收不良和药物生物利用度受损为特征的病理状态会表现为腹泻和营养不良。了解这些营养物质触发的制动机制的重要性为慢性腹泻、营养不良和药物吸收不良的未来治疗提供了重要线索。
