Huilaja Laura, Mäkikallio Kaarin, Tasanen Kaisa
OYS, medisiininen tulosalue, ihotautien klinikka ja Oulun yliopisto, ihotautien klinikka, kliinisen lääketieteen laitos.
Duodecim. 2013;129(7):731-8.
Gestational pemphigoid is a rare pruritic bullous pregnancy associated dermatosis caused by autoantibodies against placental and dermal collagen XVII. Clinically, it is characterized by severe pruritus and blisters on abdominal skin and extremities. Immunofluorescence analysis of perilesional skin is used in the diagnostics and maternal serum BP180-levels reflect the disease activity. Topical steroids and antihistamins usually relieve mild symptoms, but in severe cases oral corticosteroid is the drug-of-choice. Spontaneous recovery is common after parturition but this disease typically recurs in the following pregnancies. Due to the associated risk of prematurity and fetal growth restriction, prenatal monitoring jointly by a dermatologist and an obstetrician is recommended.
妊娠类天疱疮是一种罕见的、由针对胎盘和真皮层XVII型胶原蛋白的自身抗体引起的、伴有瘙痒性水疱的妊娠相关皮肤病。临床上，其特征为腹部皮肤和四肢出现严重瘙痒及水疱。对皮损周围皮肤进行免疫荧光分析用于诊断，母体血清BP180水平反映疾病活动度。局部使用类固醇和抗组胺药通常可缓解轻度症状，但在严重病例中，口服皮质类固醇是首选药物。分娩后通常会自然恢复，但这种疾病在随后的妊娠中通常会复发。由于存在早产和胎儿生长受限的相关风险，建议皮肤科医生和产科医生联合进行产前监测。
