Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Malaysia.
Department of Dermatology, Helios Saint Johannes Klinikum, Duisburg, Germany.
J Gynecol Obstet Hum Reprod. 2022 May;51(5):102370. doi: 10.1016/j.jogoh.2022.102370. Epub 2022 Apr 3.
Pemphigoid gestationis (PG), also known as gestational pemphigoid, as it is specifically associated with a pregnancy event, is among the rare pregnancy-related dermatoses, characterised by the formation of autoantibodies against Bullous Pemphigoid antigens 180 and 230 (BP180 and BP230), causing significant damage to the basement membrane of the skin, resulting in marked pruritus and blisters on the abdomen and extremities. Diagnosis of PG is basically made by the characteristic clinical picture and confirmed by immunofluorescence studies and histopathology of a skin biopsy. Treatment, just as for other autoimmune dermatoses, is achieved by corticosteroids with the risk of relapses in subsequent pregnancies. Fetal growth restriction and pre-maturity are potential fetal complications associated with the disease, hence the recommended combined antenatal care by a dermatologist as well as an obstetrician, however, this disease is unlikely to be a source of significant maternal morbidity or mortality.
大疱性类天疱疮（PG），也称为妊娠性类天疱疮，因为它与妊娠事件密切相关，是罕见的妊娠相关皮肤病之一，其特征是针对大疱性类天疱疮抗原 180 和 230（BP180 和 BP230）形成自身抗体，导致皮肤基底膜的显著损伤，导致腹部和四肢出现明显瘙痒和水疱。PG 的诊断基本上是根据特征性的临床图像，并通过免疫荧光研究和皮肤活检的组织病理学来确认。治疗方法与其他自身免疫性皮肤病一样，是通过皮质类固醇来实现的，但随后的妊娠中存在复发的风险。胎儿生长受限和早产是与该疾病相关的潜在胎儿并发症，因此建议皮肤科医生和妇产科医生联合进行产前护理，然而，这种疾病不太可能成为导致产妇发病率或死亡率显著增加的原因。
