Monash Alfred Psychiatry Research Centre, The Alfred and Monash University Central Clinical School, Melbourne, Victoria, Australia.
Brain Stimul. 2013 Nov;6(6):922-4. doi: 10.1016/j.brs.2013.04.006. Epub 2013 May 9.
High and low frequency repetitive transcranial magnetic stimulation (rTMS) are both used to treat major depressive disorder(MDD). However, the physiological mechanisms underlying the therapeutic benefit and the effect of the stimulation frequency are unclear. Twelve healthy participants received 1Hz, 2Hz, and 5Hz active rTMS. Twenty 5 second trains were delivered at left dorsolateral prefrontal cortex at 110% of resting motor threshold with a 25 second inter-train interval. Blood oxygenation (HbO) was significantly reduced following the 1Hz trains compared to the HbO increases observed in both the 2Hz and 5Hz conditions. There was no significant inter-hemispheric difference in response. These results suggest that short trains of high and low frequency rTMS delivered to prefrontal cortex evoke a differential HbO response and provide additional evidence that high frequency trains result in increased neural activity. The findings may provide further explanation for the improved symptoms observed in MDD patients treated with high frequency rTMS.
高频率和低频率重复经颅磁刺激（rTMS）均用于治疗重度抑郁症（MDD）。然而，治疗益处的生理机制和刺激频率的影响尚不清楚。12 名健康参与者接受了 1Hz、2Hz 和 5Hz 的主动 rTMS。在左背外侧前额叶皮层以 110%的静息运动阈值施加 20 个持续 5 秒的刺激序列，序列之间间隔 25 秒。与 2Hz 和 5Hz 条件下观察到的 HbO 增加相比，1Hz 刺激序列后 HbO 明显降低。反应没有明显的半球间差异。这些结果表明，施加于前额叶皮层的高、低频率 rTMS 短刺激序列会引起 HbO 反应的差异，并提供了额外的证据表明高频刺激会导致神经活动增加。这些发现可能进一步解释了高频 rTMS 治疗 MDD 患者症状改善的原因。
