利用卟啉-岩藻糖基乳糖杂化物对志贺毒素 1 进行靶向光降解并降低其对 Vero 细胞的细胞毒性。
Target-selective photo-degradation of verotoxin-1 and reduction of its cytotoxicity to Vero cells using porphyrin-globotriose hybrids.
机构信息
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Yokohama 223-8522, Japan.
出版信息
Chem Commun (Camb). 2013 Jul 11;49(54):6027-9. doi: 10.1039/c3cc42957a.
PMID:23722161
Abstract
Designed and synthesized porphyrin-globotriose hybrids effectively degraded verotoxin-1, which causes severe bloody diarrhoea and fetal hemolytic uremic syndrome (HUS). Degradation was achieved using long-wavelength UV or visible light irradiation in the absence of any additives and under neutral conditions. Moreover, the hybrids neutralized the cytotoxicity of verotoxin upon photo-irradiation.
摘要
设计并合成了卟啉-岩藻糖基杂化物，可有效降解志贺毒素-1，该毒素可引起严重的血性腹泻和胎儿溶血性尿毒症综合征（HUS）。在无任何添加剂和中性条件下，通过长波长紫外线或可见光照射实现了降解。此外，杂化物在光照后中和了志贺毒素的细胞毒性。
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