富勒烯-糖杂化物对HIV-1蛋白酶的靶向选择性光降解
Target-selective photo-degradation of HIV-1 protease by a fullerene-sugar hybrid.
作者信息
Tanimoto Shuho, Sakai Satoshi, Matsumura Shuichi, Takahashi Daisuke, Toshima Kazunobu
机构信息
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, 223-8522, Japan.
出版信息
Chem Commun (Camb). 2008 Nov 30(44):5767-9. doi: 10.1039/b811726h. Epub 2008 Oct 2.
DOI:10.1039/b811726h
PMID:19009075
Abstract
A designed fullerene-sugar hybrid effectively and selectively degraded the target protein, HIV-1 protease, which has high affinity for the fullerene moiety; degradation was achieved using long-wavelength UV or visible photo-irradiation, in the absence of any additives and under neutral conditions.
摘要
一种设计的富勒烯-糖杂化物能有效且选择性地降解目标蛋白HIV-1蛋白酶，该蛋白酶对富勒烯部分具有高亲和力；在没有任何添加剂的情况下，于中性条件下通过长波长紫外线或可见光照射实现了降解。
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