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照亮疾病,启迪生物医学:拉曼光谱作为一种诊断工具。

Illuminating disease and enlightening biomedicine: Raman spectroscopy as a diagnostic tool.

机构信息

School of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7ND, UK.

出版信息

Analyst. 2013 Jul 21;138(14):3871-84. doi: 10.1039/c3an00698k. Epub 2013 May 31.

DOI:10.1039/c3an00698k
PMID:23722248
Abstract

The discovery of the Raman effect in 1928 not only aided fundamental understanding about the quantum nature of light and matter but also opened up a completely novel area of optics and spectroscopic research that is accelerating at a greater rate during the last decade than at any time since its inception. This introductory overview focuses on some of the most recent developments within this exciting field and how this has enabled and enhanced disease diagnosis and biomedical applications. We highlight a small number of stimulating high-impact studies in imaging, endoscopy, stem cell research, and other recent developments such as spatially offset Raman scattering amongst others. We hope this stimulates further interest in this already exciting field, by 'illuminating' some of the current research being undertaken by the latest in a very long line of dedicated experimentalists interested in the properties and potential beneficial applications of light.

摘要

1928 年拉曼效应的发现不仅有助于对光和物质的量子性质的基本理解,而且开辟了一个全新的光学和光谱学研究领域,在过去十年中的发展速度比其诞生以来的任何时候都要快。本综述概述了该令人兴奋的领域中的一些最新发展,以及这些发展如何实现和增强疾病诊断和生物医学应用。我们强调了一些在成像、内窥镜检查、干细胞研究以及其他领域(如空间偏移拉曼散射等)的具有刺激性的高影响力研究。我们希望这将通过展示一些热衷于研究光的性质和潜在有益应用的新一代实验人员正在进行的最新研究,激发人们对这一已经令人兴奋的领域的进一步兴趣。

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