Laboratory of Microbiology, Department of Biological Sciences, Faculty of Pharmacy of University of Porto. Rua Jorge Viterbo Ferreira, Porto, Portugal.
J Med Virol. 2013 Aug;85(8):1377-8. doi: 10.1002/jmv.23619. Epub 2013 May 30.
The high mortality of pregnant women is one of the main features of hepatitis E virus (HEV) infection in endemic countries. With the emergence of genotype 3 HEV in industrialized countries, attention should be given to pregnant women from these regions since the effect of genotype 3 HEV in pregnancy is not yet known. In this study, archived sera dating from 1993 from mothers with no history of traveling to HEV endemic countries and their newborns were tested for anti-HEV IgG antibodies. Four of the 12 maternal sera were positive for IgG anti-HEV, indicating exposure to this virus. Their newborns were also positive, showing higher anti-HEV IgG levels. Overall, these findings demonstrate not only an efficient transplacental transport of anti-HEV IgG, but also circulation of autochthonous HEV in Portugal in the early 1990s.
高孕产妇死亡率是戊型肝炎病毒（HEV）感染在流行国家的主要特征之一。随着工业化国家 3 型 HEV 的出现，应该关注来自这些地区的孕妇，因为目前还不清楚 3 型 HEV 在妊娠中的作用。在这项研究中，检测了 1993 年来自无前往戊型肝炎病毒流行国家旅行史的母亲及其新生儿的存档血清，以检测抗 HEV IgG 抗体。12 份母体血清中有 4 份 IgG 抗 HEV 呈阳性，表明曾接触过这种病毒。他们的新生儿也呈阳性，表明抗 HEV IgG 水平较高。总的来说，这些发现不仅表明抗 HEV IgG 能够有效穿过胎盘，还表明 20 世纪 90 年代初葡萄牙存在本土 HEV 循环。
