Department of Immunology, University of Washington, Seattle, Washington 98195, USA.
J Clin Invest. 2013 Jul;123(7):2778-80. doi: 10.1172/JCI69670. Epub 2013 Jun 3.
Suppressing unwanted humoral immune responses without compromising the host's ability to respond to foreign pathogens is a primary goal for therapies aimed at ameliorating harmful autoantibody production. Global suppression of the immune system via lymphocyte depletion and/or immunosuppressive drugs can have off-target effects, a limitation to conventional therapies. In this issue of the JCI, Macauley and colleagues utilize a novel platform to inhibit antigen-specific antibody production that preserves the immune system's ability to respond to unrelated antigens.
抑制不必要的体液免疫反应，同时又不损害宿主对外来病原体的反应能力，这是旨在减轻有害自身抗体产生的治疗方法的主要目标。通过淋巴细胞耗竭和/或免疫抑制药物对免疫系统进行全面抑制会产生脱靶效应，这是传统疗法的一个局限性。在本期 JCI 中，Macauley 及其同事利用一种新平台来抑制抗原特异性抗体的产生，同时保留免疫系统对无关抗原的反应能力。
