• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

黄褐斑的临床研究以及当前某些可用局部治疗方法对其治疗效果的比较。

A clinical study of melasma and a comparison of the therapeutic effect of certain currently available topical modalities for its treatment.

作者信息

Sardesai Vidyadhar R, Kolte Jennifer N, Srinivas Babu N

机构信息

Department of Dermatology, STD and Leprosy, Bharati Vidyapeeth Medical College, Pune, Maharashtra, India.

出版信息

Indian J Dermatol. 2013 May;58(3):239. doi: 10.4103/0019-5154.110842.

DOI:10.4103/0019-5154.110842
PMID:23723484
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3667296/
Abstract

BACKGROUND

Melasma is a common acquired facial hypermelanosis. Conventional treatment of melasma includes a sunscreen and hypopigmenting agents. The treatment of this recalcitrant disorder is often difficult and unsatisfactory.

AIMS

The objective is to carry out a detailed clinical study of melasma and to assess the therapeutic effect and side effects of certain currently available topical modalities for the treatment of melasma.

MATERIALS AND METHODS

160 patients of all age groups and both sexes were treated sequentially with five different combination regimes for 3 months. Assessment of the response was done subjectively as well as by melasma area and severity index (MASI).

RESULTS

Out of the five modalities studied, the modified Kligman's formula was the most effective. However, it had comparatively higher incidence of side effects.

CONCLUSIONS

Among the currently available topical modalities for the treatment of melasma, the most effective combination is the modified Kligman's formula. However, in view of the side effects it causes, it must be used with caution and proper counseling.

摘要

背景

黄褐斑是一种常见的获得性面部色素沉着过度疾病。黄褐斑的传统治疗方法包括使用防晒霜和色素减退剂。这种顽固性疾病的治疗通常困难且效果不佳。

目的

对黄褐斑进行详细的临床研究，并评估某些目前可用的局部治疗方法对黄褐斑的治疗效果和副作用。

材料与方法

160例各年龄组及不同性别的患者依次接受五种不同的联合治疗方案，为期3个月。通过主观评估以及黄褐斑面积和严重程度指数（MASI）来评估疗效。

结果

在所研究的五种治疗方法中，改良的Kligman配方最为有效。然而，其副作用发生率相对较高。

结论

在目前可用的治疗黄褐斑的局部治疗方法中，最有效的组合是改良的Kligman配方。然而，鉴于其引起的副作用，必须谨慎使用并给予适当的指导。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4598/3667296/b07a73793c4e/IJD-58-239e-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4598/3667296/d50330e98fb9/IJD-58-239e-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4598/3667296/7a6dd82f511d/IJD-58-239e-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4598/3667296/f00583a0fd96/IJD-58-239e-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4598/3667296/b07a73793c4e/IJD-58-239e-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4598/3667296/d50330e98fb9/IJD-58-239e-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4598/3667296/7a6dd82f511d/IJD-58-239e-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4598/3667296/f00583a0fd96/IJD-58-239e-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4598/3667296/b07a73793c4e/IJD-58-239e-g007.jpg

相似文献

1
A clinical study of melasma and a comparison of the therapeutic effect of certain currently available topical modalities for its treatment.黄褐斑的临床研究以及当前某些可用局部治疗方法对其治疗效果的比较。
Indian J Dermatol. 2013 May;58(3):239. doi: 10.4103/0019-5154.110842.
2
Study of oral tranexamic acid, topical tranexamic acid, and modified Kligman's regimen in treatment of melasma.口服氨甲环酸、局部氨甲环酸和改良 Kligman 方案治疗黄褐斑的研究。
J Cosmet Dermatol. 2020 Jun;19(6):1456-1462. doi: 10.1111/jocd.13430. Epub 2020 Apr 28.
3
A split-face comparison of fractional erbium: YAG laser plus Kligman's formula vs. Kligman's formula monotherapy for facial melasma.面部黄褐斑的铒激光 1540nm 微剥脱联合 Kligman 公式与 Kligman 公式单药治疗的对比研究
Arch Dermatol Res. 2022 Oct;314(8):791-797. doi: 10.1007/s00403-021-02294-z. Epub 2021 Oct 27.
4
The combination of glycolic acid peels with a topical regimen in the treatment of melasma in dark-skinned patients: a comparative study.乙醇酸焕肤联合局部治疗方案用于治疗深色皮肤患者黄褐斑的对比研究
Dermatol Surg. 2002 Sep;28(9):828-32; discussion 832. doi: 10.1046/j.1524-4725.2002.02034.x.
5
A Randomized Comparative Study of Intralesional Tranexemic Acid and Kligman's Regimen in Indian Patients with Melasma.氨甲环酸皮损内注射与Kligman疗法治疗印度黄褐斑患者的随机对照研究
J Cutan Aesthet Surg. 2022 Apr-Jun;15(2):135-141. doi: 10.4103/JCAS.JCAS_1_21.
6
Safety and efficacy of topical metformin 30% cream versus triple combination cream (Kligman's formula) in treating melasma: A randomized controlled study.局部用二甲双胍 30%乳膏与三联乳膏（Kligman 配方）治疗黄褐斑的安全性和疗效：一项随机对照研究。
J Cosmet Dermatol. 2022 Jun;21(6):2508-2515. doi: 10.1111/jocd.14953. Epub 2022 Apr 9.
7
A Randomized Study to Evaluate the Efficacy of Oral Tranexamic Acid, Modified Kligman's Formula, and Placebo Cream in Melasma.一项评估口服氨甲环酸、改良Kligman配方和安慰剂乳膏治疗黄褐斑疗效的随机研究。
Indian Dermatol Online J. 2024 Aug 19;15(5):787-793. doi: 10.4103/idoj.idoj_797_23. eCollection 2024 Sep-Oct.
8
Comparison between Intralesional Triamcinolone and Kligman's Formula in Treatment of Melasma.曲安奈德皮损内注射与Kligman配方治疗黄褐斑的疗效比较
Acta Med Iran. 2016 Jan;54(1):67-71.
9
A Pilot Study to Compare Therapeutic Efficacy and Safety of Combined Treatment of Skin Microneedling and Depigmenting Cream versus Depigmenting Cream Alone in Facial Melasma at Tertiary Care Center.一项在三级护理中心进行的对比皮肤微针联合祛斑霜与单纯使用祛斑霜治疗面部黄褐斑的疗效和安全性的初步研究。
J Cutan Aesthet Surg. 2021 Apr-Jun;14(2):156-159. doi: 10.4103/JCAS.JCAS_182_19.
10
Comparative Study of Combination of Oral Tranexamic Acid With Modified Kligman's Formula Versus Oral Tranexamic Acid With Azelaic Acid 15% in the Treatment of Melasma.口服氨甲环酸联合改良Kligman配方与口服氨甲环酸联合15%壬二酸治疗黄褐斑的对比研究
Cureus. 2023 Jun 24;15(6):e40908. doi: 10.7759/cureus.40908. eCollection 2023 Jun.

引用本文的文献

1
The Efficacy of Topical Cosmetic Containing Alpha-Arbutin 5% and Kojic Acid 2% Compared With Triple Combination Cream for the Treatment of Melasma: A Split-Face, Evaluator-Blinded Randomized Pilot Study.含5%α - 熊果苷和2%曲酸的外用化妆品与三联复方乳膏治疗黄褐斑的疗效比较：一项半脸、评估者盲法随机对照试验
J Cosmet Dermatol. 2025 Jan;24(1):e16562. doi: 10.1111/jocd.16562. Epub 2024 Nov 18.
2
Combination of Hydroquinone and Fractional CO Laser versus Hydroquinone Monotherapy in Melasma Treatment: A Randomized, Single-blinded, Split-face Clinical Trial.氢醌与分次二氧化碳激光联合治疗与氢醌单药治疗黄褐斑的疗效比较：一项随机、单盲、半脸临床试验
Indian J Dermatol. 2019 Mar-Apr;64(2):129-135. doi: 10.4103/ijd.IJD_240_17.
3

本文引用的文献

1
DeoxyArbutin: a novel reversible tyrosinase inhibitor with effective in vivo skin lightening potency.脱氧熊果苷：一种新型可逆性酪氨酸酶抑制剂，具有有效的体内皮肤美白功效。
Exp Dermatol. 2005 Aug;14(8):601-8. doi: 10.1111/j.0906-6705.2005.00337.x.
2
Hydroquinone 4%, tretinoin 0.05%, fluocinolone acetonide 0.01%: a safe and efficacious 12-month treatment for melasma.4% 对苯二酚、0.05% 维甲酸、0.01% 醋酸氟轻松：一种治疗黄褐斑安全有效的12个月疗程。
Cutis. 2005 Jan;75(1):57-62.
3
A double-blind randomized trial of 5% ascorbic acid vs. 4% hydroquinone in melasma.
Updates in the understanding and treatments of skin & hair disorders in women of color.
有色人种女性皮肤和毛发疾病的认识与治疗进展
Int J Womens Dermatol. 2017 Feb 16;3(1 Suppl):S21-S37. doi: 10.1016/j.ijwd.2017.02.006. eCollection 2017 Mar.
4
Updates in the understanding and treatments of skin & hair disorders in women of color.有色人种女性皮肤和毛发疾病的认识与治疗进展
Int J Womens Dermatol. 2015 May 27;1(2):59-75. doi: 10.1016/j.ijwd.2015.04.002. eCollection 2015 Jun.
5
Extrafacial melasma over forearms.
Indian Dermatol Online J. 2016 Jul-Aug;7(4):344-5. doi: 10.4103/2229-5178.185470.
6
Etiopathogenetic factors, thyroid functions and thyroid autoimmunity in melasma patients.黄褐斑患者的发病机制、甲状腺功能及甲状腺自身免疫
Postepy Dermatol Alergol. 2015 Oct;32(5):327-30. doi: 10.5114/pdia.2015.54742. Epub 2015 Oct 29.
7
The first clinical experience on efficacy of topical flutamide on melasma compared with topical hydroquinone: a randomized clinical trial.与外用氢醌相比，外用氟他胺治疗黄褐斑疗效的首次临床经验：一项随机临床试验。
Drug Des Devel Ther. 2015 Aug 4;9:4219-25. doi: 10.2147/DDDT.S80713. eCollection 2015.
8
Melasma: a clinical and epidemiological review.黄褐斑：一项临床与流行病学综述。
An Bras Dermatol. 2014 Sep-Oct;89(5):771-82. doi: 10.1590/abd1806-4841.20143063.
一项关于5%抗坏血酸与4%对苯二酚治疗黄褐斑的双盲随机试验。
Int J Dermatol. 2004 Aug;43(8):604-7. doi: 10.1111/j.1365-4632.2004.02134.x.
4
Efficacy and safety of a new triple-combination agent for the treatment of facial melasma.一种新型三联组合制剂治疗面部黄褐斑的疗效与安全性。
Cutis. 2003 Jul;72(1):67-72.
5
Melasma treated with hydroquinone, tretinoin, and a fluorinated steroid.
Int J Dermatol. 2001 Mar;40(3):212-5. doi: 10.1046/j.1365-4362.2001.01167-2.x.
6
Wood's light in dermatology.伍德灯在皮肤病学中的应用。
Int J Dermatol. 1999 Nov;38(11):801-7. doi: 10.1046/j.1365-4362.1999.00794.x.
7
Treatment of melasma using kojic acid in a gel containing hydroquinone and glycolic acid.使用含有对苯二酚和乙醇酸的凝胶中的曲酸治疗黄褐斑。
Dermatol Surg. 1999 Apr;25(4):282-4. doi: 10.1046/j.1524-4725.1999.08236.x.
8
Intermittent therapy for melasma in Asian patients with combined topical agents (retinoic acid, hydroquinone and hydrocortisone): clinical and histological studies.
J Dermatol. 1998 Sep;25(9):587-96. doi: 10.1111/j.1346-8138.1998.tb02463.x.
9
Physiologic skin changes during pregnancy: a study of 140 cases.孕期的生理性皮肤变化：140例病例研究
Int J Dermatol. 1998 Jun;37(6):429-31. doi: 10.1046/j.1365-4362.1998.00281.x.
10
Melasma. Etiologic and therapeutic considerations.黄褐斑。病因及治疗考量。
Arch Dermatol. 1995 Dec;131(12):1453-7. doi: 10.1001/archderm.131.12.1453.