Bosamiya Sanjay S, Jain Sonal M
Department of Dermatology, Venereology, and Leprosy, Surat Municipal Institute of Medical Education and Research (SMIMER), Surat, Gujarat, India.
J Cutan Aesthet Surg. 2021 Apr-Jun;14(2):156-159. doi: 10.4103/JCAS.JCAS_182_19.
Melasma is a commonly acquired, chronic, and relapsing disorder that results in symmetrical, brownish facial pigmentation. It is more common in women than in men, which generally starts between 20 and 40 years of age, and it can lead to considerable embarrassment and distress. Managing melasma is a difficult challenge that requires long-term treatment with a number of topical agents. Microneedling has been described as a new technique to enhance the drug's transdermal penetration, and has also been reported to result in sustained long-term improvement of recalcitrant melasma.
The aim of this article was to compare the therapeutic efficacy and safety of combined treatment of skin microneedling and depigmenting cream versus depigmenting cream alone in the treatment of melasma.
A prospective study was conducted with a sample size of 40 patients, with twenty in each of the treatment arms; 20 patients were treated with combined skin needling and depigmenting cream and 20 with depigmenting cream alone. The outcome was evaluated periodically for up to 2 months using the modified Melasma Area and Severity Index (MASI) score.
Significant reduction was observed in modified MASI score in the combined treatment, with value <0.05.
Combining microneedling with Kligman's regimen gives better results in melasma treatment compared to topical treatment alone.
黄褐斑是一种常见的后天性、慢性复发性疾病，会导致面部出现对称性褐色色素沉着。女性比男性更易患此病，通常发病于20至40岁之间，会给患者带来极大的尴尬和困扰。治疗黄褐斑是一项艰巨的挑战，需要长期使用多种外用药物。微针疗法被描述为一种增强药物经皮渗透的新技术，也有报道称其能使顽固性黄褐斑得到持续长期改善。
本文旨在比较皮肤微针联合祛斑霜与单纯使用祛斑霜治疗黄褐斑的疗效和安全性。
进行了一项前瞻性研究，样本量为40例患者，每个治疗组20例；20例患者接受皮肤微针联合祛斑霜治疗，20例仅接受祛斑霜治疗。使用改良的黄褐斑面积和严重程度指数（MASI）评分对结果进行长达2个月的定期评估。
联合治疗组的改良MASI评分显著降低，P值<0.05。
与单纯外用治疗相比，微针疗法联合克利格曼疗法治疗黄褐斑效果更佳。
