• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

成人起病的特应性皮炎伴继发性毛囊黏蛋白病，合并环孢素诱导的棘状毛囊角化过度和毛发鞘。

Adult onset atopic dermatitis with secondary follicular mucinosis with cyclosporine induced spiny follicular hyperkeratosis and hair casts.

作者信息

Gutte Rameshwar M

机构信息

Department of Dermatology, Dr. L. H. Hiranandani Hospital, Powai, Mumbai, India.

出版信息

Indian J Dermatol. 2013 May;58(3):243. doi: 10.4103/0019-5154.110863.

DOI:10.4103/0019-5154.110863
PMID:23723501
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3667313/
Abstract

Secondary follicular mucinosis developing in adult patient with atopic dermatitis (AD) was observed on histology. Due to severity of disease, patient was started on oral cyclosporine 300 mg daily in 3 divided doses. Two weeks later patient started developing multiple spiny follicular keratoses mainly on face but also on extremities and trunk along with hair casts on scalp. Repeat biopsy from such keratotic lesions confirmed diagnosis spiny follicular hyperkeratosis (SFH). On investigations no evidence of multiple myeloma or any other malignancy was found. Cyclosporine was stopped and lesions cleared over 2 weeks. We report this case due to rare association of AD with follicular mucinosis and cyclosporine induced SFH with hair casts.

摘要

在组织学上观察到一名患有特应性皮炎（AD）的成年患者出现继发性毛囊黏蛋白沉积症。由于病情严重，患者开始每日口服环孢素300毫克，分3次服用。两周后，患者开始出现多个棘状毛囊角化病，主要分布在面部，但也见于四肢和躯干，同时头皮上有发鞘。对这些角化性病变进行重复活检，确诊为棘状毛囊角化过度（SFH）。检查未发现多发性骨髓瘤或任何其他恶性肿瘤的证据。停用环孢素后，病变在2周内消退。我们报告该病例是因为AD与毛囊黏蛋白沉积症以及环孢素诱导的伴有发鞘的SFH之间存在罕见关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba03/3667313/0400980da2ab/IJD-58-243b-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba03/3667313/78bdfc79450d/IJD-58-243b-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba03/3667313/b7928131a87b/IJD-58-243b-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba03/3667313/56f3807fa5b6/IJD-58-243b-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba03/3667313/8d4661c49575/IJD-58-243b-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba03/3667313/51c8d93aa587/IJD-58-243b-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba03/3667313/762c8922bdc6/IJD-58-243b-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba03/3667313/0400980da2ab/IJD-58-243b-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba03/3667313/78bdfc79450d/IJD-58-243b-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba03/3667313/b7928131a87b/IJD-58-243b-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba03/3667313/56f3807fa5b6/IJD-58-243b-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba03/3667313/8d4661c49575/IJD-58-243b-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba03/3667313/51c8d93aa587/IJD-58-243b-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba03/3667313/762c8922bdc6/IJD-58-243b-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba03/3667313/0400980da2ab/IJD-58-243b-g007.jpg

相似文献

1
Adult onset atopic dermatitis with secondary follicular mucinosis with cyclosporine induced spiny follicular hyperkeratosis and hair casts.成人起病的特应性皮炎伴继发性毛囊黏蛋白病，合并环孢素诱导的棘状毛囊角化过度和毛发鞘。
Indian J Dermatol. 2013 May;58(3):243. doi: 10.4103/0019-5154.110863.
2
Acitretin-induced spiny follicular hyperkeratosis.阿维A诱导的棘状毛囊性角化过度症。
Cutan Ocul Toxicol. 2016;35(2):165-7. doi: 10.3109/15569527.2015.1072545. Epub 2015 Aug 12.
3
Follicular mucinosis presenting as acute dermatitis and response to dapsone.
Clin Exp Dermatol. 1989 Sep;14(5):382-4. doi: 10.1111/j.1365-2230.1989.tb02592.x.
4
[Hair-like hyperkeratoses in patients with kidney transplants. A new cyclosporin side-effect].肾移植患者的毛发样角化过度。一种新的环孢素副作用
Hautarzt. 1995 Dec;46(12):841-6. doi: 10.1007/s001050050350.
5
Follicular mucinosis occurring after bone marrow transplantation in a patient with acute lymphoblastic leukemia.一名急性淋巴细胞白血病患者骨髓移植后发生毛囊黏蛋白病。
J Formos Med Assoc. 2004 Jan;103(1):63-6.
6
Follicular mucinosis. A reaction pattern in follicular epithelium.
Am J Dermatopathol. 1985 Jun;7(3):245-57.
7
Follicular mucinosis.毛囊黏蛋白病
Indian Dermatol Online J. 2013 Oct;4(4):333-5. doi: 10.4103/2229-5178.120667.
8
Follicular mucinosis and follicular mycosis fungoides: clinicopathological evaluation of seven cases.毛囊黏蛋白病和毛囊蕈样肉芽肿：7例临床病理评估
Turk Patoloji Derg. 2013;29(2):108-16. doi: 10.5146/tjpath.2013.01160.
9
Prominent follicular mucinosis with diffuse scalp alopecia resembling alopecia areata.显著毛囊黏蛋白病伴弥漫性头皮脱发，类似斑秃。
J Cutan Pathol. 2013 Oct;40(10):887-90. doi: 10.1111/cup.12201. Epub 2013 Aug 21.
10
[Chronic follicular mucinosis. Presentation of a case].
G Ital Dermatol Venereol. 1989 May;124(5):241-3.

引用本文的文献

1
A Case of Hair Cast After Isotretinoin Treatment.异维A酸治疗后毛发管型一例。
Dermatol Pract Concept. 2023 Jul 1;13(3):e2023196. doi: 10.5826/dpc.1303a196.

本文引用的文献

1
Epidemiology and clinical features of atopic dermatitis in India.印度特应性皮炎的流行病学及临床特征
Indian J Dermatol. 2011 Sep-Oct;56(5):471-5. doi: 10.4103/0019-5154.87112.
2
Cutaneous follicular hyperkeratotic spicules--the first clinical sign of multiple myeloma progression or relapse.皮肤滤泡性角化过度性棘状丘疹——多发性骨髓瘤进展或复发的首个临床体征。
Int J Dermatol. 2010 Aug;49(8):934-6. doi: 10.1111/j.1365-4632.2009.04369.x.
3
Spiny follicular hyperkeratosis eruption: a new cutaneous adverse effect of sorafenib.棘状毛囊性角化过度疹：索拉非尼一种新的皮肤不良反应。
J Clin Oncol. 2010 Nov 1;28(31):e640-2. doi: 10.1200/JCO.2010.31.3783. Epub 2010 Sep 20.
4
Atopic dermatitis in infants and children in India.印度婴幼儿特应性皮炎。
Indian J Dermatol Venereol Leprol. 2010 Sep-Oct;76(5):504-13. doi: 10.4103/0378-6323.69066.
5
Validation of the diagnostic criteria for atopic dermatitis in the adult Thai population.泰国成年人群中特应性皮炎诊断标准的验证
Asian Pac J Allergy Immunol. 2007 Jun-Sep;25(2-3):133-8.
6
Angiolymphoid hyperplasia with follicular mucinosis.伴毛囊黏蛋白沉积症的血管淋巴样增生
Indian J Dermatol Venereol Leprol. 2007 Sep-Oct;73(5):346-7. doi: 10.4103/0378-6323.35739.
7
Hair casts and cutaneous spicules in multiple myeloma.多发性骨髓瘤中的毛发管型和皮肤棘状丘疹
Arch Dermatol. 2006 Dec;142(12):1665-6. doi: 10.1001/archderm.142.12.1665.
8
Spiny keratoderma of the palms and soles - report of two cases.掌跖部棘状角化病——2例报告
Eur J Dermatol. 2000 Oct-Nov;10(7):542-5.
9
[Hair-like hyperkeratoses in patients with kidney transplants. A new cyclosporin side-effect].肾移植患者的毛发样角化过度。一种新的环孢素副作用
Hautarzt. 1995 Dec;46(12):841-6. doi: 10.1007/s001050050350.
10
Parakeratotic horns in a patient with Crohn's disease.一名克罗恩病患者出现的不全角化性角。
Clin Exp Dermatol. 1989 Jan;14(1):79-81. doi: 10.1111/j.1365-2230.1989.tb00892.x.