Izakovic J, Büchner S A, Düggelin M, Guggenheim R, Itin P H
Dermatologische Universitätsklinik, Universität Basel.
Hautarzt. 1995 Dec;46(12):841-6. doi: 10.1007/s001050050350.
We report a 31-year-old renal transplant patient treated with cyclosporin A who developed an unusual sebaceous gland hyperplasia accompanied by a disseminated follicular spiny hyperkeratosis. Those alterations were most evident on his face and limbs. In some locations hairy hyperkeratosis with authentic hair neogenesis was found. The histology of these alterations showed a marked hyperkeratosis of the hair follicles with formation of hair-like spikes either alone or in connection with hairs. The presence of true hairs distinguishes our case from the morphologically similar disseminated spiked hyperkeratosis and other spiny keratinization disorders. Scanning electron microscopy helped to demonstrate the hair-like structure of these keratoses. Some of the sebaceous glands showed cystic widening of their lumina, which were filled with abundant amorphous eosinophilic material, a finding similar to earlier observations. Our case demonstrates that these skin alterations should be classified as side effects of cyclosporin A and that they are apparently dose-dependent.
我们报告了一名31岁接受环孢素A治疗的肾移植患者，该患者出现了不寻常的皮脂腺增生，并伴有弥漫性毛囊棘状角化过度。这些改变在他的面部和四肢最为明显。在某些部位发现了伴有真性毛发新生的毛发角化过度。这些改变的组织学表现为毛囊显著角化过度，形成单独或与毛发相连的毛发样棘突。真性毛发的存在使我们的病例与形态学上相似的弥漫性棘状角化过度及其他棘状角化障碍相区别。扫描电子显微镜有助于证明这些角化病的毛发样结构。一些皮脂腺显示管腔囊性扩张，腔内充满丰富的无定形嗜酸性物质，这一发现与早期观察结果相似。我们的病例表明，这些皮肤改变应归类为环孢素A的副作用，且显然与剂量有关。
