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大鼠妊娠期发育参数的背景数据。

Background data on developmental parameters during the gestation period in rats.

作者信息

Furukawa Satoshi, Hayashi Seigo, Abe Masayoshi, Hagio Souichiro, Irie Kota, Kuroda Yusuke, Ogawa Izumi, Sugiyama Akihiko

机构信息

Biological Research Laboratories, Nissan Chemical Industries, Ltd., 1470 Shiraoka, Shiraoka, Saitama 349-0294, Japan.

出版信息

J Toxicol Pathol. 2013 Mar;26(1):83-8. doi: 10.1293/tox.26.83. Epub 2013 Apr 22.

DOI:10.1293/tox.26.83
PMID:23723574
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3620220/
Abstract

Background data during the gestation period were obtained from 128 Wistar Hannover GALAS rats and 26 Crl:CD(SD) pregnant rats in the control groups of our previous toxicity studies. The body weights of dams in the Wistar Hannover GALAS rats were significantly lower throughout the gestation period than those in the Crl:CD(SD) rats. In contrast, the time-dependent change in the body weight gain (%) of dams showed very similar trends in both strains. The mean number of live embryos/fetuses in the Wistar Hannover GALAS rats was 12.0, and was lower than that (14.5) in the Crl:CD(SD) rats. The placental weights gradually increased with pregnancy progression and reached a plateau on gestation day (GD) 19, although the embryo/fetal weights rapidly increased from GD 17 to GD 21. The embryo/fetal weights in the Wistar Hannover GALAS rats were significantly lower on only GD 21 than those in the Crl:CD(SD) rats. It is considered that this fetal weight difference between the strains develops during the fetal period, but not during the organogenesis period. In contrast, there were no differences in the placental weights between the two strains. Microscopically, the thickness of the labyrinth zone in the Wistar Hannover GALAS rats was thicker throughout the gestation period than that in the Crl:CD(SD) rats.

摘要

妊娠期间的背景数据取自我们之前毒性研究对照组中的128只Wistar Hannover GALAS大鼠和26只Crl:CD(SD)妊娠大鼠。在整个妊娠期，Wistar Hannover GALAS大鼠母鼠的体重显著低于Crl:CD(SD)大鼠。相比之下，两种品系母鼠体重增加百分比的时间依赖性变化趋势非常相似。Wistar Hannover GALAS大鼠活胚胎/胎儿的平均数量为12.0，低于Crl:CD(SD)大鼠（14.5）。胎盘重量随着妊娠进展逐渐增加，并在妊娠第19天达到平台期，而胚胎/胎儿重量从妊娠第17天到第21天迅速增加。仅在妊娠第21天，Wistar Hannover GALAS大鼠的胚胎/胎儿重量显著低于Crl:CD(SD)大鼠。据认为，品系间的这种胎儿体重差异在胎儿期形成，而非器官发生期。相比之下，两种品系的胎盘重量没有差异。显微镜下，在整个妊娠期，Wistar Hannover GALAS大鼠迷路区的厚度比Crl:CD(SD)大鼠厚。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9a1/3620220/fc0bbab58fcd/tox-26-083-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9a1/3620220/08f33e4329d6/tox-26-083-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9a1/3620220/a5eb907cf314/tox-26-083-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9a1/3620220/fc0bbab58fcd/tox-26-083-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9a1/3620220/08f33e4329d6/tox-26-083-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9a1/3620220/a5eb907cf314/tox-26-083-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9a1/3620220/fc0bbab58fcd/tox-26-083-g003.jpg

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2
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J Toxicol Pathol. 2011 Jun;24(2):95-111. doi: 10.1293/tox.24.95. Epub 2011 Jun 30.
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4
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Nutrients. 2020 Aug 21;12(9):2542. doi: 10.3390/nu12092542.
5
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J Toxicol Pathol. 2019 Jan;32(1):1-17. doi: 10.1293/tox.2018-0042. Epub 2018 Oct 15.
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J Toxicol Pathol. 2016 Oct;29(4):279-283. doi: 10.1293/tox.2016-0022. Epub 2016 May 28.
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Toxicol Pathol. 2004 Nov-Dec;32(6):659-67. doi: 10.1080/01926230490520269.