Malhotra Gaurav, Swami Archana, Shah Pinky, Mittal Neha, Gandhi Sunny J, Tiwari Bp, Jatale Praful V, Asopa Ramesh V
Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Centre Annexe, Mumbai, Maharashtra, India.
Indian J Nucl Med. 2012 Apr;27(2):115-8. doi: 10.4103/0972-3919.110709.
We report F-18 fluorodeoxyglucose (FDG) "positron emission tomography (PET) super scan" akin to "super scan" of conventional skeletal scintigraphy, in a rare case of primitive neuroectodermal tumor (PNET) of the kidney. A twelve year old male patient of metastatic PNET of the kidney was subjected to a "true" whole body F-18 FDG PET scan including lower limbs and skull region as per the institution protocol. The images revealed extensive hypermetabolic areas corresponding to the computed tomography described renal, hepatic, and pancreatic lesions along with intense and non-uniform uptake in the marrows of axial and appendicular skeletal system. Interestingly, low background tracer concentration was observed along with very low F-18 FDG uptake in the brain, skeletal muscles of limb, mediastinum, and bowel. In view of these findings, the scan can be interpreted as "PET super scan" due to its resemblance with the super scan of skeletal scintigraphy. A repeat F-18 FDG PET scan after chemotherapy revealed marked treatment response with disappearance of "super scan"-like pattern, reduction in number, size, metabolic activity of the lesions, and stimulated marrow sans the previously diseased portion. Though uncommon, the reporting physician should be aware of "PET super scan" and its implications as described in this case.
我们报告了一例罕见的肾原始神经外胚层肿瘤(PNET)患者,其F-18氟脱氧葡萄糖(FDG)“正电子发射断层扫描(PET)超级扫描”类似于传统骨闪烁显像的“超级扫描”。一名12岁患有肾转移性PNET的男性患者,按照机构方案接受了一次“真正的”全身F-18 FDG PET扫描,包括下肢和颅骨区域。图像显示,与计算机断层扫描所描述的肾脏、肝脏和胰腺病变相对应的广泛高代谢区域,以及轴向和附属骨骼系统骨髓中强烈且不均匀的摄取。有趣的是,在脑、肢体骨骼肌、纵隔和肠道中观察到低背景示踪剂浓度以及极低的F-18 FDG摄取。鉴于这些发现,由于该扫描与骨闪烁显像的超级扫描相似,可将其解释为“PET超级扫描”。化疗后重复进行的F-18 FDG PET扫描显示出显著的治疗反应,“超级扫描”样模式消失,病变数量、大小、代谢活性降低,并且先前患病部位的骨髓不再受累。尽管不常见,但报告医生应了解如本病例中所述的“PET超级扫描”及其意义。