Guducu Nilgun, Sidar Guliz, Bassullu Nuray, Turkmen Ilknur, Dunder Ilkkan
Department of Obstetrics and Gynecology, Istanbul Bilim University Istanbul, Turkey.
Int J Clin Exp Med. 2013 May 22;6(5):372-6. Print 2013.
The aim of this study was to compare the results of see-and-treat procedure with the classical three-step procedure in terms of initial cytology and LEEP reports. We searched the pathology charts of patients that had LEEP were searched retrospectively and then they were divided into 2 groups according to the presence or absence of a cervical biopsy before LEEP. There were 116 patients in the study. Of the patients with ASCUS/LSIL cytology and a positive cervical biopsy 48.4% had CIN 2-3 at LEEP, in contrast only 19% of the patients without a prior cervical biopsy had CIN 2-3 at LEEP (p=0.031); there was no statistically significant difference between the 2 procedures in patients with a HSIL and ASC-H smear result (p=0.726 and p=1.0 respectively). In conclusion patients with ASC-H and HSIL cytology see-and-treat approach seems more advantageous, avoids delay in treatment, noncompliance and risk of skipping lesions at biopsy.
本研究的目的是在初始细胞学和利普刀报告方面，比较即检即治程序与经典三步程序的结果。我们对接受利普刀治疗的患者的病理图表进行了回顾性检索，然后根据利普刀治疗前是否进行宫颈活检将患者分为两组。本研究共有116例患者。在非典型鳞状细胞/低度鳞状上皮内病变（ASCUS/LSIL）细胞学检查且宫颈活检呈阳性的患者中，48.4%在利普刀治疗时患有2-3级宫颈上皮内瘤变（CIN），相比之下，未进行过宫颈活检的患者中只有19%在利普刀治疗时患有CIN 2-3级（p=0.031）；在高度鳞状上皮内病变（HSIL）和非典型鳞状细胞不除外高度鳞状上皮内病变（ASC-H）涂片结果的患者中，两种程序之间无统计学显著差异（分别为p=0.726和p=1.0）。总之，对于ASC-H和HSIL细胞学检查的患者，即检即治方法似乎更具优势，可避免治疗延迟、不依从以及活检时漏诊病变的风险。
