Noviello Maria de Lourdes Meirelles, Batista Nathália Vieira, Dourado Luana Pereira Antunes, Cara Denise Carmona
Departmento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Antônio Carlos 6627, Pampulha, 31270-901 Belo Horizonte, MG, Brazil.
ISRN Allergy. 2011 Dec 1;2011:818239. doi: 10.5402/2011/818239. Print 2011.
Food allergy frequently precedes or coexists with respiratory allergy, and although restriction of contacts with the allergen is the elected clinical procedure, oral immunotherapy (OIT) has proven to be surprisingly efficient in clinical trials. We investigated whether prolonged restriction and voluntary exposure of previously sensitized (immunized) mice to ovalbumin (OVA) in the drinking water would alter subsequent responses to bronchial (aerosol) challenge with OVA. We found a significant suppression of bronchial inflammation, with marked reduction of eosinophils. IL-4, CCL-2, and CCL-11 are not associated with elevation in IL-10 production or Foxp3 expression, with only minor digestive symptoms.
食物过敏常常先于呼吸道过敏出现或与之并存，尽管避免接触过敏原是首选的临床治疗方法，但口服免疫疗法（OIT）在临床试验中已被证明具有惊人的疗效。我们研究了让先前致敏（免疫）的小鼠长期限制接触并自愿接触饮用水中的卵清蛋白（OVA），是否会改变其随后对OVA支气管（气雾剂）激发的反应。我们发现支气管炎症得到了显著抑制，嗜酸性粒细胞明显减少。白细胞介素-4（IL-4）、趋化因子配体2（CCL-2）和趋化因子配体11（CCL-11）与白细胞介素-10（IL-10）产生增加或叉头框蛋白3（Foxp3）表达升高无关，仅伴有轻微的消化症状。
