Gelencsér Zsolt, Galbáts Borisz, Gonzalez Juan F, Choudhary K Sonal, Hudaiberdiev Sanjarbek, Venturi Vittorio, Pongor Sándor
Faculty of Information Technology, Pázmány Péter Catholic University, Práter u. 50/a, 1083 Budapest, Hungary.
ISRN Microbiol. 2012 Feb 29;2012:484176. doi: 10.5402/2012/484176. Print 2012.
Pseudomonas spp. are able to colonize a large variety of environments due to their wide adaptability which is also associated with an N-acyl homoserine lactone (AHL) gene regulation mechanism called quorum sensing (QS). In this article we present a systematic overview of the genomic arrangement patterns of quorum sensing genes found in Pseudomonas and compare the topologies with those found in other bacterial genomes. We find that the topological arrangement of QS genes is more variable than previously thought but there are a few unifying features that occur in many of the topological arrangements. We hypothesize that the negative regulators of QS that are often found between the canonical luxR/ and luxI-family genes may be crucial for stabilizing the output of QS circuits.
假单胞菌属能够在多种环境中定殖，这归因于它们广泛的适应性，这种适应性还与一种名为群体感应（QS）的N-酰基高丝氨酸内酯（AHL）基因调控机制相关。在本文中，我们系统概述了假单胞菌中发现的群体感应基因的基因组排列模式，并将其拓扑结构与其他细菌基因组中的拓扑结构进行比较。我们发现，群体感应基因的拓扑排列比之前认为的更具变异性，但在许多拓扑排列中存在一些统一特征。我们推测，常在典型的luxR/和luxI家族基因之间发现的群体感应负调控因子可能对稳定群体感应回路的输出至关重要。
