Faculty of Information Technology, PázmányPéter Catholic University, Práter u. 50/a, Budapest 1083, Hungary.
Sensors (Basel). 2012;12(5):5432-44. doi: 10.3390/s120505432. Epub 2012 Apr 27.
Virulence and adaptability of many Gram-negative bacterial species are associated with an N-acylhomoserine lactone (AHL) gene regulation mechanism called quorum sensing (QS). The arrangement of quorum sensing genes is variable throughout bacterial genomes, although there are unifying themes that are common among the various topological arrangements. A bioinformatics survey of 1,403 complete bacterial genomes revealed characteristic gene topologies in 152 genomes that could be classified into 16 topological groups. We developed a concise notation for the patterns and show that the sequences of LuxR regulators and LuxI autoinducer synthase proteins cluster according to the topological patterns. The annotated topologies are deposited online with links to sequences and genome annotations at http://bacteria.itk.ppke.hu/QStopologies/.
许多革兰氏阴性细菌的毒力和适应性与一种称为群体感应 (QS) 的 N-酰基高丝氨酸内酯 (AHL) 基因调控机制有关。尽管在各种拓扑排列中存在共同的统一主题，但群体感应基因的排列在细菌基因组中是可变的。对 1403 个完整细菌基因组的生物信息学调查显示，在 152 个基因组中存在特征性的基因拓扑结构，可以将其分类为 16 个拓扑组。我们为这些模式开发了一种简洁的符号表示法，并表明 LuxR 调节剂和 LuxI 自动诱导合成酶蛋白的序列根据拓扑模式聚类。已注释的拓扑结构在线存储，并链接到 http://bacteria.itk.ppke.hu/QStopologies/ 上的序列和基因组注释。
