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药物过量:一次洗胃够吗?

Drug overdoses: Is one stomach washing enough?

作者信息

Sharman J R, Cretney M J, Scott R D, Janus E D

出版信息

N Z Med J. 1975 Feb 26;81(534):195-7.

PMID:237248
Abstract

Naso-gastric tube aspirates were taken from patients with drug overdoses who had been given a gastric lavage and admitted to the resuscitation ward. Although care was taken to conduct thorough washouts, it was found that these were not always efficient. In several cases an amount equivalent to a therapeutic dose of drug was recovered in later aspirates. There was no correlation between the amount of drug recovered in the initial stomach washings and that found in the aspirates. It was concluded that routine aspiration of gastric contents at hourly intervals after admission was of considerable value in removing any residual drugs.

摘要

对接受过洗胃并入住复苏病房的药物过量患者采集鼻胃管吸出物。尽管已采取措施进行彻底冲洗,但发现这些冲洗并不总是有效。在几例病例中,后续吸出物中回收了相当于治疗剂量的药物。初始洗胃中回收的药物量与吸出物中发现的药物量之间没有相关性。得出的结论是,入院后每隔一小时常规抽吸胃内容物对于清除任何残留药物具有相当大的价值。

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引用本文的文献

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Mixtures of prion substrains in natural scrapie cases revealed by ovinised murine models.天然瘙痒病病例中朊病毒亚株的混合物通过羊源化的鼠模型揭示。
Sci Rep. 2020 Mar 19;10(1):5042. doi: 10.1038/s41598-020-61977-1.
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Poisoning by drug overdose.药物过量中毒
Can Med Assoc J. 1977 Sep 3;117(5):424-9.
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Poisoning with enteric-coated acetylsalicylic acid complicating gastric outlet obstruction.肠溶包衣阿司匹林中毒并发胃出口梗阻
Can Med Assoc J. 1980 May 10;122(9):1032-4.
4
Abandon gastric lavage in the accident and emergency department?在急诊科放弃洗胃?
Arch Emerg Med. 1984 Jun;1(2):65-71. doi: 10.1136/emj.1.2.65.
5
Antidepressant overdosage.抗抑郁药过量服用。
Drugs. 1982 Jun;23(6):431-61. doi: 10.2165/00003495-198223060-00002.
6
Gastric emptying. Risk versus benefit in the treatment of acute poisoning.胃排空。急性中毒治疗中的风险与获益
Med Toxicol. 1986 Mar-Apr;1(2):142-53. doi: 10.1007/BF03259833.
7
Poisoning due to tricyclic antidepressant overdosage. Clinical presentation and treatment.三环类抗抑郁药过量中毒。临床表现与治疗。
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