Pedrosa Rogerio G, Donato Jose, Pires Ivanir S, Tirapegui Julio
Department of Integrated Education in Health, CCS, Federal University of Espírito Santo, Vitória, Brazil.
Appl Physiol Nutr Metab. 2013 Jun;38(6):694-7. doi: 10.1139/apnm-2012-0440. Epub 2013 Mar 27.
This study evaluated the effect of leucine on the protein status of rats submitted to 50% food restriction for 1 week, followed by 2 weeks of nutritional recovery. A significant increase of serum insulin-like growth factor 1 and protein/RNA ratio in the liver was observed in leucine-supplemented rats. There was no change in carcass, liver, or gastrocnemius protein content when compared with control animals. The supplementation tested did not favor protein status, although it improved some indicators of an anabolic state.
本研究评估了亮氨酸对大鼠蛋白质状态的影响。这些大鼠先接受1周50%的食物限制，随后进行2周的营养恢复。在补充亮氨酸的大鼠中，观察到血清胰岛素样生长因子1显著增加，肝脏中的蛋白质/RNA比率也显著增加。与对照动物相比，大鼠的胴体、肝脏或腓肠肌蛋白质含量没有变化。尽管所测试的补充剂改善了一些合成代谢状态指标，但对蛋白质状态并无促进作用。
