Department of Dermatology, Rouen University Hospitals, 1 Rue de Germont, 76000, Rouen, France.
Br J Dermatol. 2013 Oct;169(4):931-3. doi: 10.1111/bjd.12454.
The incidence of scabies is increasing in Europe, and it often affects children and infants. Although numerous topical treatments have been approved for treatment of scabies in adults, they are often poorly tolerated in infants. One treatment, ivermectin, remains off label for infants weighing < 15 kg.
To report our experience on the safety and efficacy of oral ivermectin in refractory scabies in infants.
A retrospective study was performed in the dermatology and paediatrics departments of Rouen University Hospital between January 2009 and October 2012. Infants diagnosed with scabies were identified, and the data for those fulfilling the inclusion criteria were analysed.
Of 219 infants identified, 15 had received oral ivermectin and had been followed up for at least 3 months. All 15 patients were given two doses of ivermectin, 200 μg kg(-1), at baseline and 14 days later. Of 14 patients contacted 1 month after treatment, 12 had achieved healing. The other two were treated with ivermectin or benzyl benzoate; both healed. Overall, 3 months after the first ivermectin treatment, 13/14 patients had healed and only one had active disease.
Ivermectin is generally well tolerated in infants. The 80% rate of healing observed in infants who had failed to respond to at least two other topical treatments suggests that ivermectin could be considered for treatment of infants with recalcitrant or relapsing scabies.
疥疮在欧洲的发病率正在上升，它经常影响儿童和婴儿。尽管有许多局部治疗方法已被批准用于治疗成人疥疮，但它们在婴儿中往往难以耐受。一种治疗药物伊维菌素，对于体重<15 公斤的婴儿仍然是超说明书用药。
报告我们在难治性婴儿疥疮中使用口服伊维菌素的安全性和疗效经验。
在 2009 年 1 月至 2012 年 10 月期间，我们在鲁昂大学医院的皮肤科和儿科部门进行了一项回顾性研究。确定了诊断为疥疮的婴儿，并对符合纳入标准的数据进行了分析。
在 219 名婴儿中，有 15 名接受了口服伊维菌素治疗，并至少随访了 3 个月。所有 15 名患者均在基线时和 14 天后接受了两次伊维菌素剂量，200μg/kg。在治疗后 1 个月联系的 14 名患者中，12 名已经治愈。另外两名患者接受了伊维菌素或苯甲酸苄酯治疗；两者均治愈。总体而言，在首次伊维菌素治疗后 3 个月，14 例患者中有 13 例治愈，只有 1 例仍有活动性疾病。
伊维菌素在婴儿中通常耐受性良好。在至少两种其他局部治疗方法治疗失败的婴儿中，观察到 80%的愈合率表明，伊维菌素可考虑用于治疗难治性或复发性疥疮的婴儿。
