Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran.
Arch Iran Med. 2013 Jun;16(6):348-50.
This study was conducted to determine the impact of hepatitis B virus (HBV) as a cause of hepatocellular carcinoma (HCC) in a single liver transplant center in Iran.
We included all hepatectomy specimens from patients with HBV-related cirrhosis who underwent transplants from May 1993 until January 2012 in this study. From these, we determined the number that had HBV-induced HCC. Nested PCR results were used to determine the HBV genotype from sections of the hepatectomy pathology specimens.
During this time period there were 1361 cirrhotic livers transplanted in our center. Of these, 249 were attributed to HBV cirrhosis. Overall, HCC was detected in 40 (2.9%) subjects, of which 29 (1.2%) had HBV-related HCC. Genotype D was only genotype observed in all HBV subjects.
The results revealed that although HBV-related cirrhosis was the most frequent single cause for liver transplant, the frequency of HBV-induced HCC was very low among transplant recipients. Out of 1361 transplant recipients, only 29 (2.1%) were diagnosed with HBV-related HCC. All HBV subjects had genotype D.
本研究旨在确定乙型肝炎病毒（HBV）作为伊朗单一肝移植中心肝细胞癌（HCC）病因的影响。
我们纳入了本研究中所有在 1993 年 5 月至 2012 年 1 月期间因 HBV 相关肝硬化接受移植的肝切除术标本，以确定其中有多少例为 HBV 诱导的 HCC。从这些标本中，我们使用巢式 PCR 结果确定肝切除术病理学标本部分的 HBV 基因型。
在此期间，我们中心有 1361 例肝硬化肝脏接受了移植。其中，249 例归因于 HBV 肝硬化。总体而言，40 例（2.9%）患者检测到 HCC，其中 29 例（1.2%）为 HBV 相关性 HCC。所有 HBV 患者均仅观察到基因型 D。
结果表明，尽管 HBV 相关肝硬化是肝移植最常见的单一病因，但在移植受者中，HBV 诱导的 HCC 发生率非常低。在 1361 例移植受者中，仅有 29 例（2.1%）被诊断为 HBV 相关性 HCC。所有 HBV 患者均为基因型 D。
