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一项针对进展期胰腺和肝胆癌患者预先医疗计划的心肺复苏视频的随机对照试验。

A randomized controlled trial of a cardiopulmonary resuscitation video in advance care planning for progressive pancreas and hepatobiliary cancer patients.

机构信息

Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

出版信息

J Palliat Med. 2013 Jun;16(6):623-31. doi: 10.1089/jpm.2012.0524. Epub 2013 Apr 22.

Abstract

BACKGROUND

Cardiopulmonary resuscitation (CPR) is an important advance directive (AD) topic in patients with progressive cancer; however such discussions are challenging.

OBJECTIVE

This study investigates whether video educational information about CPR engenders broader advance care planning (ACP) discourse.

METHODS

Patients with progressive pancreas or hepatobiliary cancer were randomized to an educational CPR video or a similar CPR narrative. The primary end-point was the difference in ACP documentation one month posttest between arms. Secondary end-points included study impressions; pre- and post-intervention knowledge of and preferences for CPR and mechanical ventilation; and longitudinal patient outcomes.

RESULTS

Fifty-six subjects were consented and analyzed. Rates of ACP documentation (either formal ADs or documented discussions) were 40% in the video arm (12/30) compared to 15% in the narrative arm (4/26), OR=3.6 [95% CI: 0.9-18.0], p=0.07. Post-intervention knowledge was higher in both arms. Posttest, preferences for CPR had changed in the video arm but not in the narrative arm. Preferences regarding mechanical ventilation did not change in either arm. The majority of subjects in both arms reported the information as helpful and comfortable to discuss, and they recommended it to others. More deaths occurred in the video arm compared to the narrative arm, and more subjects died in hospice settings in the video arm.

CONCLUSIONS

This pilot randomized trial addressing downstream ACP effects of video versus narrative decision tools demonstrated a trend towards more ACP documentation in video subjects. This trend, as well as other video effects, is the subject of ongoing study.

摘要

背景

心肺复苏术(CPR)是进展性癌症患者重要的预先指示(AD)话题;然而,此类讨论颇具挑战性。

目的

本研究旨在探讨心肺复苏术教育视频是否能促进更广泛的预先医疗指令(ACP)讨论。

方法

患有进展性胰腺或肝胆癌的患者被随机分配至观看教育性 CPR 视频或阅读类似 CPR 叙事的干预组。主要终点为干预后一个月两组间 ACP 文件记录的差异。次要终点包括研究印象、CPR 和机械通气的预先及干预后知识和偏好、以及患者的纵向结局。

结果

共纳入 56 名患者并进行分析。视频组(30 名中的 12 名)和叙事组(26 名中的 4 名)的 ACP 文件记录(正式 AD 或记录的讨论)率分别为 40%和 15%,OR=3.6[95%CI:0.9-18.0],p=0.07。两组干预后的知识均有所提高。干预后,视频组的 CPR 偏好发生了变化,而叙事组则没有。两组的机械通气偏好均无变化。两组大多数患者均报告称该信息有助于讨论且感觉舒适,他们还向他人推荐了该信息。视频组的死亡人数多于叙事组,视频组中有更多的患者在临终关怀机构中去世。

结论

本探索性随机试验针对视频与叙事决策工具对下游 ACP 影响进行了研究,结果显示视频组的 ACP 文件记录呈增加趋势。这一趋势以及其他视频效果是正在进行的研究主题。

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