肉桂叶化学成分的研究

Chemical constituents of Cinnamomum cebuense.

机构信息

Chemistry Department and Center for Natural Sciences and Ecological Research, De La Salle University, Manila, Philippines.

出版信息

Chin J Nat Med. 2013 May;11(3):264-8. doi: 10.1016/S1875-5364(13)60026-6.

DOI:10.1016/S1875-5364(13)60026-6

PMID:23725839

Abstract

AIM

To investigate the chemical constituents of Cinnamomum cebuense, an endemic and critically endangered tree found only in Cebu, Philippines.

METHODS

The compounds were isolated by silica gel chromatography. The structures of the isolates were elucidated by NMR spectroscopy.

RESULTS

The dichloromethane (DCM) extract of the bark of C. cebuense afforded a new monoterpene natural product 1 and a new sesquiterpene 2, along with the known compounds, 4-hydroxy-3-methoxycinnamaldehyde (3), 4-allyl-2-methoxyphenol (4), α-terpineol (5) and humulene (6). The DCM extract of the leaves of C. cebuense yielded 6, β-caryophyllene (7), squalene (8), and a mixture of α-amyrin (9), β-amyrin (10) and bauerenol (11). The structures of 1-7 were elucidated by extensive 1D and 2D NMR spectroscopy, while the structures of 8-11 were identified by comparison of their (13)C NMR data with those reported in the literature.

CONCLUSION

The bark of C. cebuense afforded monoterpenes, sesquiterpenes and phenolics, while the leaves yielded sesquiterpenes and triterpenes.

摘要

目的

研究仅在菲律宾宿务发现的地方特有且极度濒危的树种锡兰肉桂的化学成分。

方法

化合物通过硅胶色谱法分离。通过 NMR 光谱解析分离物的结构。

结果

锡兰肉桂树皮的二氯甲烷（DCM）提取物提供了一种新的单萜天然产物 1 和一种新的倍半萜 2，以及已知化合物 4-羟基-3-甲氧基肉桂醛（3）、4-丙烯基-2-甲氧基苯酚（4）、α-松油醇（5）和葎草烯（6）。锡兰肉桂叶的 DCM 提取物产生了 6、β-石竹烯（7）、角鲨烯（8）以及 α-香树精（9）、β-香树精（10）和波瑞醇（11）的混合物。通过 1D 和 2D NMR 光谱的广泛解析确定了 1-7 的结构，而通过与文献中报道的数据进行比较确定了 8-11 的结构。