INSERM U783 Développement du système immunitaire, Université Paris Descartes, Faculté de Médecine, Site Broussais, 96 rue Didot, Paris, France.
Curr Opin Immunol. 2013 Jun;25(3):334-8. doi: 10.1016/j.coi.2013.05.004. Epub 2013 May 28.
B cell memory has long been considered the attribute of the sole IgG-positive B cell subset. Since a few years, and due to new B-cell subset identification procedures, increasing heterogeneity has been identified among the memory B cell pool. IgM-positive cells and germinal center-independent subsets are recent additions to the field. This review describes the diversity of memory B cells, as well as controversial issues on their relative contribution to the recall response. The impact of a protracted germinal center response to the specific mobilization of IgM memory B cells is proposed.
B 细胞记忆长期以来被认为是唯一 IgG 阳性 B 细胞亚群的特征。由于近年来新的 B 细胞亚群鉴定程序的出现，记忆 B 细胞池中发现了越来越多的异质性。IgM 阳性细胞和生发中心非依赖性亚群是该领域的最新发现。本综述描述了记忆 B 细胞的多样性，以及关于它们对回忆反应相对贡献的争议问题。提出了生发中心反应持续时间对特定 IgM 记忆 B 细胞动员的影响。
