Immunology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Int Immunol. 2012 Jul;24(7):403-8. doi: 10.1093/intimm/dxs050. Epub 2012 Mar 26.
B-cell memory describes the populations of cells that provide long-term humoral immunity: long-lived antibody-secreting plasma cells that reside mainly in the bone marrow and memory B cells. Interestingly, the memory B-cell population is heterogenous, although the importance of this heterogeneity has been unclear. Recent studies have investigated the formation and function of memory in different settings. In particular, T-independent memory-like cells and T-dependent (TD) IgM memory B cells qualitatively differ from canonical TD class-switched memory B cells; however, these studies suggest that IgM memory cells preserve the memory population over long periods of time. These subsets are evocative of the evolution of the humoral immune response, with memory-like cells appearing before acquisition of germinal centers, suggesting that there are multiple pathways to producing B-cell memory.
B 细胞记忆描述了提供长期体液免疫的细胞群体：主要存在于骨髓中的长寿抗体分泌浆细胞和记忆 B 细胞。有趣的是，尽管记忆 B 细胞群体的异质性很重要，但这种异质性的重要性尚不清楚。最近的研究调查了不同环境下记忆的形成和功能。特别是，T 细胞非依赖性记忆样细胞和 T 细胞依赖性（TD）IgM 记忆 B 细胞在性质上不同于经典的 TD 类别转换记忆 B 细胞；然而，这些研究表明，IgM 记忆细胞在很长一段时间内保留记忆群体。这些亚群让人联想到体液免疫反应的演变，记忆样细胞出现在生发中心获得之前，这表明产生 B 细胞记忆有多种途径。
