Fuss M, Pepersack T, Bergman P, Hurard T, Simon J, Corvilain J
Department of Internal Medicine, Brugmann Hospital, Brussels, Belgium.
Br J Urol. 1990 Jun;65(6):560-3. doi: 10.1111/j.1464-410x.1990.tb14819.x.
The bone mineral content of the radius was measured in 32 male renal stone formers, 18 of them presenting with idiopathic urolithiasis and 14 with primary hyperparathyroidism, a disease known to disturb bone metabolism. The idiopathic stone formers had been on regular treatment with a low calcium diet. The bone mineral content of the radius was reduced to a similar level in both groups of patients. The data suggest that idiopathic stone formers on a low calcium diet are at risk of osteopenia; the factors which could lead to a negative calcium balance included uncompensated renal hypercalciuria, hypophosphataemia and exaggerated serum levels of 1,25-dihydroxyvitamin D. To treat idiopathic hypercalciuria, thiazide diuretics, which reduce the renal excretion of calcium and have been shown to be beneficial for bone, seem safer than a low calcium diet.
对32名男性肾结石患者的桡骨骨矿物质含量进行了测量，其中18人患有特发性尿石症，14人患有原发性甲状旁腺功能亢进症，这是一种已知会干扰骨代谢的疾病。特发性结石患者一直在接受低钙饮食的常规治疗。两组患者的桡骨骨矿物质含量均降至相似水平。数据表明，接受低钙饮食的特发性结石患者有骨质减少的风险；导致钙负平衡的因素包括未代偿性肾性高钙尿症、低磷血症和1,25-二羟基维生素D血清水平过高。对于治疗特发性高钙尿症，噻嗪类利尿剂可减少肾脏对钙的排泄，且已证明对骨骼有益，似乎比低钙饮食更安全。
