Fuss M, Pepersack T, Van Geel J, Corvilain J, Vandewalle J C, Bergmann P, Simon J
Department of Internal Medicine, Hôpital Universitaire Brugmann, Brussels, Belgium.
Calcif Tissue Int. 1990 Jan;46(1):9-13. doi: 10.1007/BF02555818.
The possibility that low-calcium intake in renal stone formers could lead to reduced bone mineral content was investigated in 123 male patients with idiopathic urolithiasis. Radius bone mineral content (BMC) was measured by single photon absorptiometry. Two groups of patients were analyzed: group 1 (n = 63) maintained on a free diet; group 2 (n = 60) maintained on a low-calcium diet (350 mg/day +/- 20 SEM) for 3.9 years +/- 0.6 SEM. The two groups of patients were investigated after a standard reduction of calcium intake for at least 1 week. The urinary excretion of calcium and of hydroxyproline, and the serum alkaline phosphatase activity were higher in both groups than in normal subjects submitted to the same low-calcium diet. Both groups of stone formers showed lowered radius BMC values at 3 cm (distal) and 8 cm (proximal) above the styloid process, but distal BMC was significantly lower in group 2 than in group 1. The results suggest that low-calcium intake could worsen the already decreased BMC of idiopathic renal stone formers.
在123例特发性尿路结石男性患者中，研究了肾结石患者低钙摄入导致骨矿物质含量降低的可能性。采用单光子吸收法测量桡骨骨矿物质含量（BMC）。分析了两组患者：第1组（n = 63）维持自由饮食；第2组（n = 60）维持低钙饮食（350毫克/天±20标准误）3.9年±0.6标准误。两组患者在标准钙摄入量减少至少1周后进行研究。两组患者的尿钙和羟脯氨酸排泄量以及血清碱性磷酸酶活性均高于接受相同低钙饮食的正常受试者。两组结石形成者在茎突上方3厘米（远端）和8厘米（近端）处的桡骨BMC值均降低，但第2组的远端BMC明显低于第1组。结果表明，低钙摄入可能会使特发性肾结石患者本已降低的BMC进一步恶化。
