Tizki S, Lasry F, Elftoiki F Z, Hadj Khalifa H, Itri M, Khadir K, Benchikhi H
Unité de néphrologie pédiatrique, pédiatrie III, hôpital d'enfants Abderrahim-Harouchi, CHU Ibn Rochd, rue El Faidouzi, Casablanca, Maroc.
Arch Pediatr. 2013 Jul;20(7):768-71. doi: 10.1016/j.arcped.2013.04.022. Epub 2013 May 29.
Subcutaneous fat necrosis is an uncommon disease that may be complicated with potentially fatal hypercalcemia or with nephrocalcinosis. We report on the case of a patient with a history of significant perinatal asphyxia, hospitalized for a urinary tract infection. Lesions of subcutaneous fat necrosis were noted, with asymptomatic hypercalcemia at 3.9mmol/L. A renal ultrasound was performed and showed echogenic medullary pyramids bilaterally, consistent with nephrocalcinosis and left nephrolithiasis. The treatment of hypercalcemia included hyperhydration, a diuretic and corticosteroids. Progression was characterized by the total regression of skin lesions and normalization of serum calcium. Hypercalcemia is a rare complication of subcutaneous fat necrosis. It develops within days to weeks after the appearance of skin lesions. Nephrocalcinosis appears after several weeks or months. Hypercalcemia must be treated in due time to avoid the impact on the kidney.
皮下脂肪坏死是一种罕见疾病，可能并发潜在致命的高钙血症或肾钙质沉着症。我们报告一例有严重围产期窒息史的患者，因尿路感染住院。发现有皮下脂肪坏死病变，血钙为3.9mmol/L，无症状。进行了肾脏超声检查，显示双侧肾髓质锥体呈高回声，符合肾钙质沉着症及左肾结石表现。高钙血症的治疗包括补液、使用利尿剂和糖皮质激素。病情进展表现为皮肤病变完全消退及血钙恢复正常。高钙血症是皮下脂肪坏死的一种罕见并发症。它在皮肤病变出现后的数天至数周内发生。肾钙质沉着症在数周或数月后出现。必须及时治疗高钙血症以避免对肾脏产生影响。
