Gomes Cláudia, Lobo Luísa, Azevedo António Siborro, Simão Carla
Departamento de Pediatria. Hospital de Santa Maria. Lisboa. Portugal.
Acta Med Port. 2015 Jan-Feb;28(1):119-22. Epub 2015 Feb 27.
Subcutaneous fat necrosis of the newborn is an uncommon, transient and self-healing panniculits. This entity generally follows an uncomplicated course, however there are rare and important complications. The authors present a case of a newborn with subcutaneous fat necrosis complicated by hypercalcemia and nephrocalcinosis. The pathogenesis of hypercalcemia is not fully understood and the nephrocalcinosis can evolve to chronic kidney disease. Clinicians should be aware of subcutaneous fat necrosis as a possible risk factor for hypercalcemia and patients should have serial serum and urinary calcium determinations for up to 6 months after the appearance of the skin lesions. The early diagnosis and prompt treatment of hypercalcemia are essential to prevent severe complications.
新生儿皮下脂肪坏死是一种罕见的、短暂的且可自愈的脂膜炎。该病症通常病程简单，但也存在罕见且严重的并发症。作者报告了一例新生儿皮下脂肪坏死并发高钙血症和肾钙质沉着症的病例。高钙血症的发病机制尚未完全明确，肾钙质沉着症可能会发展为慢性肾脏病。临床医生应意识到皮下脂肪坏死可能是高钙血症的一个风险因素，并且在皮肤病变出现后的6个月内，患者应定期进行血清和尿钙测定。高钙血症的早期诊断和及时治疗对于预防严重并发症至关重要。
