miR-211 通过靶向 TGFβRII 促进头颈部癌的进展。
miR-211 promotes the progression of head and neck carcinomas by targeting TGFβRII.
机构信息
Institute of Oral Biology, National Yang-Ming University, Taipei, Taiwan.
出版信息
Cancer Lett. 2013 Aug 28;337(1):115-24. doi: 10.1016/j.canlet.2013.05.032. Epub 2013 May 29.
miR-211 up-regulation and transforming growth factor-β type II receptor (TGFβRII) down-regulation are associated with poor prognosis of head and neck squamous cell carcinoma (HNSCC). miR-211 directly targets TGFβRII with the miR-211-TGFβRII-c-Myc axis promoting HNSCC progression. An inverse correlation of miR-211 and TGFβRII expression was found in metastatic HNSCC samples. After 4-nitroquinoline 1-oxide induction, more severe epithelial tumorigenesis was detected on K14-miR-211 transgenic mouse dorsal tongues. Human metastatic lesions and mouse tongue tumors showed increased nuclear c-Myc expression. A novel role for miR-211 in the regulation of TGFβRII and c-Myc during tumorigenesis being revealed should help to develop anti-HNSCC therapies.
miR-211 的上调和转化生长因子-β 型 II 受体 (TGFβRII) 的下调与头颈部鳞状细胞癌 (HNSCC) 的预后不良有关。miR-211 通过 miR-211-TGFβRII-c-Myc 轴直接靶向 TGFβRII，促进 HNSCC 进展。在转移性 HNSCC 样本中发现 miR-211 和 TGFβRII 表达呈负相关。在 4-硝基喹啉 1-氧化物诱导后，在 K14-miR-211 转基因小鼠的舌背上检测到更严重的上皮肿瘤形成。人类转移性病变和小鼠舌肿瘤显示核 c-Myc 表达增加。miR-211 在肿瘤发生过程中对 TGFβRII 和 c-Myc 的调节作用的新发现，应该有助于开发抗 HNSCC 疗法。
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