人类连接组学——未来的需求是什么？
Human connectomics - what will the future demand?
机构信息
Oxford Centre for Functional MRI of Brain, Nuffield Dept of Clinical Neurosciences, University of Oxford, Oxford, UK.
出版信息
Neuroimage. 2013 Oct 15;80:541-4. doi: 10.1016/j.neuroimage.2013.05.082. Epub 2013 May 29.
Abstract
Significant resources are now being devoted to large-scale international studies attempting to map the connectome - the brain's wiring diagram. This review will focus on the use of human neuroimaging approaches to map the connectome at a macroscopic level. This emerging field of human connectomics brings both opportunities and challenges. Opportunities arise from the ability to apply a powerful toolkit of mathematical and computational approaches to interrogate these rich datasets, many of which are being freely shared with the scientific community. Challenges arise in methodology, interpretability and biological or clinical validity. This review discusses these challenges and opportunities and highlights potential future directions.
摘要
现在，大量资源正被投入到试图绘制连接组图谱的大型国际研究中，连接组图谱描绘的是大脑的布线图。本文将重点介绍在宏观层面上使用人类神经影像学方法来绘制连接组图谱。这一新兴的人类连接组学领域带来了机遇和挑战。机遇源于能够应用强大的数学和计算方法工具包来研究这些丰富的数据集，其中许多数据集正在与科学界免费共享。在方法学、可解释性和生物学或临床有效性方面存在挑战。本文讨论了这些挑战和机遇，并强调了潜在的未来方向。
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本文引用的文献
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