植物乳杆菌OLL2712调节高脂饮食喂养的C57BL/6小鼠的葡萄糖代谢。
Lactobacillus plantarum OLL2712 regulates glucose metabolism in C57BL/6 mice fed a high-fat diet.
作者信息
Sakai Tohru, Taki Tomoyo, Nakamoto Akiko, Shuto Emi, Tsutsumi Rie, Toshimitsu Takayuki, Makino Seiya, Ikegami Shuuji
机构信息
Department of Public Health and Applied Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Kuramoto, Tokushima, Japan.
出版信息
J Nutr Sci Vitaminol (Tokyo). 2013;59(2):144-7. doi: 10.3177/jnsv.59.144.
The aim of the present study was to determine the effect of oral administration of Lactobacillus plantarum OLL2712 (L. plantarum OLL2712) on glucose and lipid metabolism in mice with high-fat diet-induced obesity. Mice that had been administered 10(9) cfu heat-killed L. plantarum OLL2712 for 12 wk showed significant reduction of blood glucose levels in response to insulin. Furthermore, mRNA expression of interleukin-1β in adipose tissue and serum levels of nonesterified fatty acids in mice administered L. plantarum OLL2712 were significantly lower than those in control mice. These results indicate that L. plantarum OLL2712 regulates glucose metabolism.
本研究的目的是确定口服植物乳杆菌OLL2712（L. plantarum OLL2712）对高脂饮食诱导肥胖小鼠的葡萄糖和脂质代谢的影响。给予10(9) cfu热灭活植物乳杆菌OLL2712 12周的小鼠，对胰岛素的反应显示血糖水平显著降低。此外，给予植物乳杆菌OLL2712的小鼠脂肪组织中白细胞介素-1β的mRNA表达和血清中非酯化脂肪酸水平显著低于对照小鼠。这些结果表明植物乳杆菌OLL2712可调节葡萄糖代谢。
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