1 Department of Food and Biotechnology, Korea University , Sejong City, Republic of Korea.
2 R&D Center , Bioland, Gyeonggi, Republic of Korea.
J Med Food. 2016 Sep;19(9):823-9. doi: 10.1089/jmf.2016.3674.
Obesity is viewed as a serious public health problem. This study aimed to investigate the antiobesity effects of fermented garlic extract by lactic acid bacteria (LAFGE) on obesity. Male C57BL/6J mice were fed with high-fat diet (HFD) to induce obesity. The HFD-induced obese mice were orally administrated with 250 or 500 mg/kg LAFGE for 8 weeks. Feeding HFD-fed mice with 250 or 500 mg/kg LAFGE reduced body weight by 14% and 18%, respectively, compared to HFD. HFD-fed mice with 500 mg/kg LAFGE administration had lower epididymal, retroperitoneal, and mesenteric adipose tissue mass by 36%, 44%, and 63%, respectively, compared to HFD. The concentration of plasma triacylglyceride and total cholesterol was significantly lower in the HFD-fed mice with LAFGE administration. Moreover, LAFGE supplementation suppressed adipogenesis by downregulation in mRNA and protein expression of PPARγ, C/EBPα, and lipogenic proteins, including SREBP-1c, FAS, and SCD-1. Based on these findings, LAFGE may ameliorate diet-induced obesity by inhibiting adipose tissue hypertrophy by suppressing adipogenesis.
肥胖被视为严重的公共卫生问题。本研究旨在探讨经乳酸菌发酵的大蒜提取物（LAFGE）对肥胖的抗肥胖作用。雄性 C57BL/6J 小鼠喂食高脂肪饮食（HFD）以诱导肥胖。HFD 诱导肥胖的小鼠经口给予 250 或 500mg/kg LAFGE 共 8 周。与 HFD 相比，喂食 250 或 500mg/kg LAFGE 的 HFD 喂养小鼠体重分别减轻了 14%和 18%。与 HFD 相比，喂食 500mg/kg LAFGE 的 HFD 喂养小鼠的附睾、腹膜后和肠系膜脂肪组织质量分别降低了 36%、44%和 63%。LAFGE 给药的 HFD 喂养小鼠的血浆三酰甘油和总胆固醇浓度显著降低。此外，LAFGE 补充通过下调 PPARγ、C/EBPα 和脂肪生成蛋白（包括 SREBP-1c、FAS 和 SCD-1）的 mRNA 和蛋白表达来抑制脂肪生成。基于这些发现，LAFGE 可能通过抑制脂肪生成来抑制脂肪组织肥大，从而改善饮食诱导的肥胖。
