纳武利尤单抗治疗患者的中枢神经系统单纯疱疹和水痘带状疱疹病毒感染。
Central nervous system herpes simplex and varicella zoster virus infections in natalizumab-treated patients.
机构信息
US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Surveillance and Epidemiology, Silver Spring, MD 20993, USA.
出版信息
Clin Infect Dis. 2013 Sep;57(6):849-52. doi: 10.1093/cid/cit376. Epub 2013 May 31.
PMID:23728144
Abstract
We report on 20 natalizumab-treated patients with multiple sclerosis who developed laboratory-confirmed central nervous system (CNS) herpesvirus infections. In addition to progressive multifocal leukoencephalopathy, other CNS opportunistic infections have been rarely reported during natalizumab treatment. We encourage heightened awareness due to the risk for serious outcomes.
摘要
我们报告了 20 例接受那他珠单抗治疗的多发性硬化症患者，这些患者发生了实验室确诊的中枢神经系统（CNS）疱疹病毒感染。除进行性多灶性白质脑病外，在那他珠单抗治疗期间，其他 CNS 机会性感染也很少有报道。由于存在严重后果的风险，我们鼓励提高警惕。
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