整合素的功能分割。
Job-splitting among integrins.
出版信息
Nat Cell Biol. 2013 Jun;15(6):575-7. doi: 10.1038/ncb2770.
DOI:10.1038/ncb2770
PMID:23728465
Abstract
How different integrin receptors for the same extracellular ligand transduce distinct cellular responses is unclear. The characterization of the class-specific adhesomes of β1 and αV integrins now shows that whereas αV integrins promote unbranched actin polymerization, β1 integrins induce myosin-II-dependent contractility, and both integrin subtypes synergistically mediate rigidity sensing.
摘要
不同的整合素受体如何对相同的细胞外配体转导不同的细胞反应尚不清楚。β1 和 αV 整合素的类特异性黏着斑的特征现在表明，虽然 αV 整合素促进无分支肌动蛋白聚合，但 β1 整合素诱导肌球蛋白-II 依赖性收缩性，并且这两种整合素亚型协同介导刚性感知。
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